116686-15-8 Usage
Uses
COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID.
Biological Activity
Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E 2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo . Anti-inflammatory.
Check Digit Verification of cas no
The CAS Registry Mumber 116686-15-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,6,8 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 116686-15:
(8*1)+(7*1)+(6*6)+(5*6)+(4*8)+(3*6)+(2*1)+(1*5)=138
138 % 10 = 8
So 116686-15-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
116686-15-8Relevant articles and documents
Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxymethanesulfonanilide derivatives
Tsuji,Nakamura,Konishi,Okumura,Matsuo
, p. 2399 - 2409 (2007/10/02)
Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.
