116686-65-8

Basic information

• Product Name: 2'-(2,4-difluorophenoxy)-4'-(methylthio)methanesulfonanilide
• Synonyms: 2'-(2,4-difluorophenoxy)-4'-(methylthio)methanesulfonanilide
• CAS NO: 116686-65-8
• Molecular Weight: 345.391
• Mol File: 116686-65-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-(2,4-difluorophenoxy)-4'-(methylthio)methanesulfonanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(2,4-difluorophenoxy)-4'-(methylthio)methanesulfonanilide(116686-65-8)
• EPA Substance Registry System: 2'-(2,4-difluorophenoxy)-4'-(methylthio)methanesulfonanilide(116686-65-8)

Safety Data

• Hazardous Substances Data: 116686-65-8(Hazardous Substances Data)

Upstream product

• 146139-80-2 3-(2,4-difluorophenoxy)-4-nitroacetanilide 
• 116687-60-6 2',4'-difluoro-5-methylthio-2-nitrodiphenylether 
• 116687-59-3 3-(2,4-difluorophenoxy)-4-nitrothiophenol 
• 116687-57-1 3-(2,4-difluorophenoxy)-4-nitroaniline 
• 712-33-4 3-chloro-4-nitroacetanilide 
• 367-27-1 2,4-difluorophenol 
• 124-63-0 methanesulfonyl chloride 
• 116687-38-8 2-(2,4-Difluoro-phenoxy)-4-methylsulfanyl-phenylamine 

Relevant articles and documents

Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxymethanesulfonanilide derivatives

Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.