116707-86-9Relevant articles and documents
Synthesis and Evaluation of N-guanidine Analogues as Potential Histamine H2-Receptor Antagonists
El-Badry, Ossama M.,Knaus, Edward E.,McNeill, John H.
, p. 1106 - 1109 (2007/10/02)
A series of N,N''-dimethoxycarbonyl-N'-guanidines (4) and N-phenyl-N'-ureas (7), thioureas (8) and cyanoguanidines (9) have been synthesized.The 4-pyridyl analogues 4c and 8c are elaborated to the respective 1,2-dihydropyridyl derivatives 5 and 10.Pharmacological testing using the histamine induced guinea pig atria chronotropic response indicates that compounds 4, 5 and 7-10 having terminal N-methoxycarbonyl and N-phenyl substituents, respectively are devoid of histamine H2-receptor antagonistic activity.
