116708-02-2Relevant academic research and scientific papers
Synthesis of C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines: Binding studies on opioid receptors
Frances,Gouarderes,Moisand,Cros,Jimonet,Moy,Chiaroni,Riche,Grierson,Husson
, p. 369 - 381 (2007/10/02)
The racemic C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines 8a-k were prepared in three steps from the readily available 2-cyano-1,2,5,6-tetrahydropyridines 4a-c. This involved alkylation of the anion of 4a-c with the appropriate alkyl ha
2-CYANO Δ3 PIPERIDEINES XIV : FACILE SYNTHESIS OF 1-SUBSTITUTED BENZOMORPHANS
Jimonet, P.,Grierson, D.S.,Husson, H.-P.
, p. 6179 - 6182 (2007/10/02)
Two complementary routes have been developed for the preparation of the key intermediate 7 leading to a series of 1-substituted benzomorphans 8.Final cyclization to the title compounds was achieved under standard Grewe conditions (HBr, Δ).
