116708-11-3

Upstream product

• 73657-70-2 2-cyano-1,3,4-trimethyl-3-piperideine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 143950-93-0 2-(p-anisyl)-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 143950-95-2 2,2-bis(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 143950-92-9 2-(o-anisyl)-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 116708-08-8 (2R,6R)-3,6,11-Trimethyl-2-phenyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol 
• 143951-05-7 2-(1'-cyclohexen)-yl-3,6,11α-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine 
• 116708-08-8 2-phenyl-3,6,11α-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine 
• 143951-08-0 1-(p-hydroxybenzyl)-2-aza-6-oxo-2,5,9-trimethylbicyclo<3.3.1>nonan-7-one 
• 143951-13-7 4-((1S,9S,13R)-9,12,13-Trimethyl-8-oxa-12-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-1-ylmethyl)-phenol 
• 116708-02-2 2-allyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 143950-99-6 2-carboethoxymethyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 143950-96-3 2-(1'-cyclohexenyl)-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 116708-03-3 2-phenyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 143950-98-5 2-(3'-butenyl)-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine 
• 116708-01-1 2-(p-methoxybenzyl)-1,2,3,4-tetramethyl-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Synthesis of C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines: Binding studies on opioid receptors

The racemic C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines 8a-k were prepared in three steps from the readily available 2-cyano-1,2,5,6-tetrahydropyridines 4a-c. This involved alkylation of the anion of 4a-c with the appropriate alkyl ha

2-CYANO Δ3 PIPERIDEINES XIV : FACILE SYNTHESIS OF 1-SUBSTITUTED BENZOMORPHANS

Two complementary routes have been developed for the preparation of the key intermediate 7 leading to a series of 1-substituted benzomorphans 8.Final cyclization to the title compounds was achieved under standard Grewe conditions (HBr, Δ).