1167444-75-8Relevant academic research and scientific papers
Synthesis of tetrasubstituted pyrroles from terminal alkynes and imines
Hu, Yancheng,Wang, Chunxiang,Wang, Dongping,Wu, Fan,Wan, Boshun
, p. 3146 - 3149 (2013/07/26)
Tetrasubstituted pyrroles can be obtained via the reaction of terminal alkynes and imines using nBuLi as the base in one step with high chemoselectivity (method 1). Alternatively, the intermediate propargylamines can also react with imines to afford tetrasubstituted pyrroles when using LiHMDS as the base (method 2), which provides a complementary method to construct the pyrroles with different substituents.
Catalytic deprotonative functionalization of propargyl silyl ethers with imines
Naka, Hiroshi,Koseki, Daiki,Kondo, Yoshinori
experimental part, p. 1901 - 1906 (2009/08/07)
A metal-free, catalytic C-H functionalization of propargyl silyl ethers with imines using the phosphazene base (t-Bu-P4 base) provides structurally defined multisubstituted pyrroles in modest to excellent yields under mild conditions. A one-pot, three-component reaction using silylated acetylenes, aldehydes, and imines is also presented.
