116748-52-8Relevant academic research and scientific papers
A concise approach to the preparation of 2-hydroxydiarylketones by an intramolecular acyl radical ipso substitution
Motherwell,Vazquez
, p. 9667 - 9671 (2000)
Substituted 2-hydroxydiarylketones have been simply prepared using an intramolecular acyl radical [1,6] ipso substitution reaction. (C) 2000 Elsevier Science Ltd.
Thiazole amide compound and preparation method, pharmaceutical composition and application thereof
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Paragraph 0207; 0231; 0250; 0251; 0252, (2019/01/08)
The invention discloses a thiazole amide compound and a preparation method thereof, a pharmaceutical composition and application thereof. The thiazole amide compound as shown in a formula I and a pharmaceutically acceptable salt thereof are provided, and
Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β- chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo
Xu, Hui,Zhang, Jun-Liang
scheme or table, p. 5177 - 5180 (2011/10/02)
In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 14 novel 4α- arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives were stereoselectively semisynthesized from podophyllotoxin, an
Novel sulfonate derivatives: Potent antimitotic agents
Gwaltney II, Stephen L.,Imade, Hovis M.,Li, Qun,Gehrke, Laura,Credo,Warner, Robert B.,Lee, Jang Yun,Kovar, Peter,Frost, David,Ng, Shi-Chung,Sham, Hing L.
, p. 1671 - 1673 (2007/10/03)
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprote
Studies on the Conformation of 5,15-Diarylporphyrins with (Arylsulfonyl)oxy Substituents
Sanders, Georgine M.,Dijk, Marinus van,Veldhuizen, Albertus van,Plas, Henk C. van der,Hofstra, Ulbert,Schaafsma, Tjeerd J.
, p. 5272 - 5281 (2007/10/02)
Dimeso-substituted octaalkylporphyrins, carrying an (arylsulfonyl)oxy group at the ortho position of the two (meso) phenyl groups, were synthesized from dipyrrolylmethanes and aldehydes.On account of a 1H NMR upfield shift in CDCl3 solution of 2-5 ppm for the aryl protons, a folded conformation is assumed in which the substituted aryl groups lie right above and below the porphyrin plane.In CDCl3/CF3COOH solution the upfield shifts are absent.The results of low-temperature 1H NMR measurements and ring-current calculations agreed with our assumptions.The sulfonyloxy group promotes folding of the molecule more than the ester, sulfonyl, sulfinyl, thio, or methylene group.In zinc porphyrins carrying anthraquinone substituents, intramolecular coordination was observed. ΔG, ΔH, and ΔS values for the various conformational equilibria were calculated from the NMR data.We suggest van der Waals interactions with a contribution of charge transfer as the driving force for the folding of the molecule.
