116753-55-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Aminopropoxy)benzonitrile is used as an intermediate for the synthesis of various drugs, contributing to the development of new medicinal compounds due to its unique chemical structure and reactivity.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 4-(3-Aminopropoxy)benzonitrile serves as an intermediate, playing a crucial role in the creation of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Organic Electronic Materials Development:
4-(3-Aminopropoxy)benzonitrile is utilized in the development of organic electronic materials, capitalizing on its chemical properties to improve the performance of organic electronic devices such as organic light-emitting diodes (OLEDs) and organic solar cells.
Used in Dyes and Pigments Production:
4-(3-Aminopropoxy)benzonitrile is also used as a component in the production of dyes and pigments, where its chemical structure contributes to the color and stability of these products in various applications, including textiles, plastics, and printing inks.

InChI:InChI=1/C10H12N2O/c11-6-1-7-13-10-4-2-9(8-12)3-5-10/h2-5H,1,6-7,11H2

Upstream product

• 1247807-88-0 C₁₀H₁₀N₄O 
• 767-00-0 4-cyanophenol 
• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 156-87-6 propan-1-ol-3-amine 
• 313476-81-2 4-[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]benzonitrile 

Downstream Products

• 103524-90-9 4-{3-[4-Cyano-5-methyl-4-(3,4,5-trimethoxy-phenyl)-hexylamino]-propoxy}-benzonitrile 
• 596810-38-7 tert-butyl 4-{(tert-butoxycarbonyl)[3-(4-cyanophenoxy)propyl]amino}butyl[3-(4-cyanophenoxy)propyl]carbamate 
• 103524-92-1 4-(3-{[4-Cyano-5-methyl-4-(3,4,5-trimethoxy-phenyl)-hexyl]-methyl-amino}-propoxy)-benzonitrile 

Relevant academic research and scientific papers

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies

The trypanosome alternative oxidase (TAO), a mitochondrial enzyme involved in the respiration of the bloodstream form trypomastigotes of Trypanosoma brucei, is a validated drug target against African trypanosomes. Earlier series of TAO inhibitors having a 2,4-dihydroxy-6-methylbenzoic acid scaffold ( head ) and a triphenylphosphonium or quinolin-1-ium cation as a mitochondrion-targeting group ( tail ) were shown to be nanomolar inhibitors in enzymatic and cellular assays. We investigated here the effect of different mitochondrion-targeting cations and other scaffold modifications on the in vitro activity of this class of inhibitors. Low micromolar range activities were obtained, and the structure-activity relationship studies showed that modulation of the tail region with polar substituents is generally detrimental to the enzymatic and cellular activity of TAO inhibitors.

From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions

We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe3+), which are readily prepared from anilines (ArNR′2, R′=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as KOtBu or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR′2. It is scalable and compatible with a wide range of functional groups.

Bispidine compounds useful in the treatment of cardiac arrythmias

There is provided compounds of formula I, 1 wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43 R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF

An arylamidine derivative represented by a general formula described below or a salt thereof has an excellent antifungal action and high safety, and it is useful as an antifungal agent with good pharmacokinetics and pharmacodynamic properties: wherein X represents an unsubstituted or substituted lower alkylene or alkenylene group; G1 represents an oxygen atom, a sulfur atom, or an imino group; G2 represents a carbon atom or a nitrogen atom; Ra represents at least one group selected from the group consisting of a hydrogen atom, a halogen atom, and unsubstituted or substituted alkyl, cycloalkyl and alkoxy groups; R1 represents an unprotected or protected or unsubstituted or substituted amidino group; and R2 represents a substituted amino or substituted cyclic amino group, or the like.