116757-19-8Relevant articles and documents
Iodine-catalysed versatile sulfenylation of indoles with thiophenols: controllable synthesis of mono- and bis-arylthioindoles
Zhang, Hailei,Bao, Xiaoze,Song, Yuming,Qu, Jingping,Wang, Baomin
, p. 8885 - 8891 (2015)
A versatile method for the synthesis of mono- and bis-arylthioindoles via I2 catalysed direct oxidative sulfenylation of indoles with thiophenols (especially mercaptobenzoic acids) has been presented. This system features environmental friendliness, easy operation, and mild reaction conditions, and shows a broad functional group tolerance furnishing good to excellent yields.
Synthesis of 3-Sulfenylindoles from Indoles and Various Sulfenylation Agents through Aerobic Oxidative C-S Bond Coupling
Xu, Chaorong,Yi, Shanli,Li, Meichao,Hu, Xinquan,Sun, Nan,Jin, Liqun,Hu, Baoxiang,Shen, Zhenlu
, p. 1914 - 1920 (2018)
A novel aerobic catalytic oxidation system for the sulfenylation of indoles with a variety of sulfenylation agents through oxidative C-S bond coupling has been successfully developed. The reactions were performed with potassium iodide as the catalyst, sodium nitrite as the co-catalyst, and molecular oxygen as the terminal oxidant in the presence of acetic acid. Under the optimal reaction conditions, a number of indoles could be sulfenylated with Bunte salts, thiols, or disulfides to generate 3-sulfenylindoles in good yields. This protocol provided an efficient and environmentally benign strategy for the synthesis of 3-sulfenylindoles.
A New Synthesis of 3-Arylthioindoles
Atkinson, Joseph G.,Hamel, Pierre,Girard, Yves
, p. 480 - 481 (1988)
The reaction of the anions of indoles with diaryl disulfides in dimethylformamide at room temperature gives the 3-arylthioindoles in 59-91percent yield.
Synthesis of 3-sulfenylindoles by Pd (II) nanoclusters confined within metal-organic framework fibers in aqueous solution
Zhiani, Rahele,Sadeghzadeh, Seyed Mohsen,Emrani, Shokufe,Abasian, Maryam
, p. 1 - 6 (2018)
We have found that fibrous nanosilica (KCC-1) can used as a excellent support for the synthesis of highly sparse nanoparticles. KCC-1 has high surface area that was functionalized with 1,3-bis(dimethylthiocarbamoyloxy)benzene groups acting as the strong performers so that the Pd (II) was complex without aggregation on the fibers of the KCC-1 microspheres (KCC-1/BTB/Pd). For synthesis of 3-sulfenylindoles from aryl iodide, indoles, and thiourea used from the KCC-1/BTB/Pd NPs as a catalyst that showed excellent catalytic activities under green conditions. Compared with the traditional substrate, KCC-1/BTB/Pd substantially increases protection and the accessibility of the nanoparticle sites due to its three dimensional hierarchical structure.
3 - Mercapto of indole compounds synthesized by catalytic oxidation method (by machine translation)
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Paragraph 0026; 0027; 0029; 0031; 0033; 0035; 0037; 0039, (2018/10/11)
The invention discloses a 3 - mercapto of indole compounds synthesized by catalytic oxidation method, to indole compounds and sulfur on behalf of the sulfate as the substrate of reaction, to potassium iodide and sodium nitrite as catalyst, in order to acetic acid as an auxiliary agent, in order to oxygen as the oxidizing agent, the reaction substrate in the organic solvent, for normal pressure, temperature 50 - 80 °C reaction under the condition of, after the reaction is completed after the separation and processed to obtain the 3 - mercapto-indole compounds. The synthesizing method of the invention, simple and safe operation, in order to clean the oxygen as terminal oxidant, thereby greatly reducing the environmental costs; mild reaction conditions. (by machine translation)
Catalytic oxidation synthesis method of 3-mercaptoindole compounds with disulfide as sulfur source
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Paragraph 0026; 0027; 0029; 0030; 0031; 0033; 0035; 0037, (2018/09/12)
The invention discloses a catalytic oxidation synthesis method of 3-mercaptoindole compounds with disulfide as a sulfur source. The method comprise steps as follows: indole compounds and disulfide aretaken as reaction substrates, potassium iodide and sodi
Cs2CO3-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Thiols with Phosphonates and Arenes
Song, Song,Zhang, Yiqun,Yeerlan, Adeli,Zhu, Bencong,Liu, Jianzhong,Jiao, Ning
supporting information, p. 2487 - 2491 (2017/02/23)
An efficient Cs2CO3-catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late-stage synthesis and modification of bioactive molecules.
Catalytic Synthesis of 3-Thioindoles Using Bunte Salts as Sulfur Sources under Metal-Free Conditions
Qi, Hong,Zhang, Tongxin,Wan, Kefeng,Luo, Meiming
, p. 4262 - 4268 (2016/06/09)
An efficient catalytic method for the synthesis of 3-thioindoles has been successfully developed, which uses odorless, stable, readily available crystalline Bunte salts as the sulfenylating agents, iodine as nonmetallic catalyst, and DMSO as both the oxid
Preparation method of 3-indole thioether
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Paragraph 0015, (2016/10/08)
According to the invention, Bunte salt is employed as a sulfur source to prepare 3-indole thioether. At a certain temperature, elementary iodine or hydroiodic acid and salts thereof is employed as a catalyst, dimethyl sulfoxide is employed as an oxidant,
Metal-free, iodine-catalyzed regioselective sulfenylation of indoles with thiols
Yi, Shanli,Li, Meichao,Mo, Weimin,Hu, Xinquan,Hu, Baoxiang,Sun, Nan,Jin, Liqun,Shen, Zhenlu
, p. 1912 - 1916 (2016/04/19)
An iodine-catalyzed regioselective sulfenylation of indoles in the presence of DMSO has been presented. Various indoles can react with aryl thiols or alkyl thiols to afford their corresponding 3-sulfenylindoles in good to excellent yields. The notable fea
