116757-23-4

Upstream product

• 948-65-2 2-phenyl-indole 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 696-63-9 4-Methoxybenzenethiol 
• 54006-72-3 3-bromo-2-phenyl-1H-indole 
• 13141-38-3 2-phenylethynylaniline 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 
• 199277-23-1 1-azido-2-(phenylethynyl)benzene 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Electron Donor-Acceptor Complex-Mediated Aerobic Sulfenylation of Indoles under Visible-Light Conditions

An efficient B(C6F5)3-catalyzed aerobic oxidative C-S cross-coupling reaction of thiophenol with indoles was developed, affording a wide range of diaryl sulfides in good yields. An electron donor-acceptor complex between B(C6F5)3 and indoles was formed, facilitating the photoinduced single-electron transfer (SET) from indole substrates to the B(C6F5)3 catalyst. This protocol demonstrates a new reaction model using B(C6F5)3 as a single-electron oxidant.

Microwave assisted metal-/oxidant-free cascade electrophilic sulfenylation/5-endo-dig cyclization of 2-alkynylanilines to generate diversified 3-sulfenylindoles

A metal-/oxidant-free sustainable protocol for the synthesis of 3-sulfenylindoles based on electrophilic cyclization of 2-alkynylanilines has been developed under microwave irradiation. Herein, catalytic amount of iodine and stoichiometric amount of sulfonyl hydrazides were employed as catalyst and electrophiles respectively to induce the 5-endo-dig cyclization of 2-alkynylanilines. This strategy allows a wide substrate scope, demonstrates good functional group tolerance, utilizes easily available reagents and overcome multistep synthesis.

C–S and C–N bond formation via Mn-promoted oxidative cascade reaction: Synthesis of C3-sulfenated indoles

Thioethers are of synthetic value in pharmaceutical molecules and nature products, herein, we report an oxidative cascade reaction that delivers multiple substituted indole thioethers with great efficiency. This transformation utilized ortho-azido aromati

Assembly of 3-Sulfenylbenzofurans and 3-Sulfenylindoles by Palladium-Catalyzed Cascade Annulation/Arylthiolation Reaction

A novel and efficient palladium-catalyzed cascade annulation/arylthiolation reaction has been developed to afford functionalized 3-sulfenylbenzofuran and 3-sulfenylindole derivatives in moderate to good yields from readily available 2-alkynylphenols and 2

Metal-free synthesis of 3-sulfenylindoles via an iodine-mediated electrophilic cyclisation of 2-alkynylanilines with disulfides

An efficient and metal-free method was developed to synthesise 3-sulfenylindoles via the iodine-mediated electrophilic cyclisation of 2-alkynylanilines with disulfides. In the presence of I2, various 3-sulfenylindoles were obtained in moderate

Palladium-catalyzed annulation of 2-(1-Alkynyl)benzenamines with disulfides: Synthesis of 3-sulfenylindoles

3-Sulfenylindoles can be efficiently prepared in moderate to good yields from 2-(1-alkynyl)benzenamines and disulfides using the palladium/air catalytic systems. The study also provides a useful route to the synthesis of fipronil analogues.

Nucleophilic reactions in the indole series: displacement of bromine under phase transfer catalysis

A novel synthetic approach for the synthesis of 3-substituted indoles by nucleophilic substitution of 3-bromo derivatives under phase transfer catalysis (PTC) was reported.

A New Synthesis of 3-Arylthioindoles

The reaction of the anions of indoles with diaryl disulfides in dimethylformamide at room temperature gives the 3-arylthioindoles in 59-91percent yield.