116795-47-2Relevant academic research and scientific papers
Ruthenium Catalyzed Selective Hydroboration of Carbonyl Compounds
Kaithal, Akash,Chatterjee, Basujit,Gunanathan, Chidambaram
supporting information, p. 4790 - 4793 (2015/10/12)
Using the [Ru(p-cymene)Cl2]2 (1) complex, catalytic hydroboration of aldehydes and ketones with pinacolborane under neat and mild conditions is reported. At rt, chemoselective hydroboration of aldehydes over the ketones is also attained. Mechanistic studies confirmed the immediate formation of monohydride bridged dinuclear complex [{(μ6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1b) from the reaction of 1 with pinacolborane, which catalyzed the highly efficient hydroboration reactions. The catalytic cycle containing mononuclear Ru-H species and intramolecular 1,3-hydride transfer is postulated.
EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF
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Page/Page column 27-28, (2010/02/14)
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
