3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL

Base Information

• Chemical Name: 3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL
• CAS No.: 116795-47-2
• Molecular Formula: C7H6BrClO2
• Molecular Weight: 237.48
• Hs Code.: 2908199090
• Mol file: 116795-47-2.mol

Synonyms:RARECHEM AL BD 0302;3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL;BENZENEMETHANOL, 3-BROMO-5-CHLORO-2-HYDROXY

Chemical Property of 3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL

Chemical Property:

• Melting Point: 64-66℃
• Boiling Point: 297.6±20.0 °C(Predicted)
• PKA: 7.96±0.23(Predicted)
• PSA: 40.46000
• Density: 1.829±0.06 g/cm3(Predicted)
• LogP: 2.30040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-chloro-2-hydroxybenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL

There total 2 articles about 3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-chlorosalicylaldehyde (19652-32-5) → 2-bromo-4-chloro-6-(hydroxymethyl)phenol (116795-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: [RhCl₂(p-cymene)]2 / benzene / 4 h / 20 °C / Inert atmosphere; Glovebox

2: hydrogenchloride; water / methanol / 1 h / Reflux

With hydrogenchloride; [RhCl₂(p-cymene)]2; water; In methanol; benzene;

DOI:10.1021/acs.orglett.5b02352

Reference yield:

C13H17BBrClO4 → 2-bromo-4-chloro-6-(hydroxymethyl)phenol (116795-47-2)

Guidance literature:

With hydrogenchloride; water; In methanol; for 1h; Reflux;

DOI:10.1021/acs.orglett.5b02352

Reference yield: 94.0%

4-Methoxybenzenethiol (696-63-9) + 2-bromo-4-chloro-6-(hydroxymethyl)phenol (116795-47-2) → 2-bromo-4-chloro-6-[((4-methoxyphenyl)thio)methyl]phenol

Guidance literature:

With iodine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1002/asia.201800233

upstream raw materials:

3-bromo-5-chlorosalicylaldehyde

Downstream raw materials:

(3-bromo-5-chloro-2-hydroxybenzyl)(triphenyl)phosphonium bromide