116798-35-7

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 2462-34-2 L-valine benzyl ester hydrochloride 
• 885623-75-6 (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-methyl-butyric acid 2-[(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl)-dimethyl-silanyl]-ethyl ester 
• 100-39-0 benzyl bromide 
• 13734-41-3 t-Boc-L-valine 
• 72-18-4 L-valine 
• 66447-55-0 ((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 21760-98-5 L-valine benzyl ester 

Downstream Products

• 60209-59-8 (N-tert-butoxycarbonyl-L-alanyl)-L-valine 
• 575488-55-0 Boc-L-Ala-L-Val-L-Amp-OtBu 
• 575488-60-7 cyclo(D-PhSeAla-L-Ala-L-Val-L-Amp) 
• 575488-58-3 Boc-D-PhSeAla-L-Ala-L-Val-L-Amp-OtBu 
• 215029-48-4 H₂N-Ala-Val-OBn 

Relevant academic research and scientific papers

Iminophosphorane-mediated synthesis of cyclic guanidines: Application to the synthesis of a simplified NA22598A1 analogue

Reaction of Cbz-protected β-amino azides with bis(diphenylphosphino) butane and tosyl isocyanate provides differentially substituted 2-iminoimidazolidines in good yields. Georg Thieme Verlag Stuttgart.

Fluorous (trimethylsilyl)ethanol: A new reagent for carboxylic acid tagging and protection in peptide synthesis

Starting with a fluorous analogue of 2-(trimethylsilyl)ethanol, we have designed an easy method for preparing a new fluorous tag (FTMSE) for the protection of carboxylic acids. Because mild conditions are employed in the tag cleavage (TBAF in the presence of 4 A molecular sieves, which prevent racemization), this tag can be advantageously used in the synthesis of peptides and modified peptides, as we have demonstrated with several examples, including the fluorous synthesis of short α- and β-peptides as well as of modified fluorinated retropeptides.

Synthesis of the amide analog of alternariolide (AM-toxin I), a host specific phytotoxin for apple leaves

The amide analog of alternariolide (AM-toxin I) was synthesized with high efficiency. The analog showed comparable biological activity to that of alternariolide.