116808-95-8

Upstream product

• 3013-38-5 2,4-dinitrobenzyl bromide 
• 3425-46-5 potassium selenocyanate 
• 610-57-1 2,4-dinitrobenzyl chloride 

Downstream Products

• 114105-44-1 tert-Butyl-[(1S,3R,4R)-3-(2,4-dinitro-phenyl)-2-selena-bicyclo[2.2.2]oct-5-en-6-yloxy]-dimethyl-silane 
• 114082-90-5 tert-Butyl-[(1S,3R,4R)-3-(2,4-dinitro-phenyl)-2-selena-bicyclo[2.2.2]oct-5-en-5-yloxy]-dimethyl-silane 

Relevant academic research and scientific papers

Tetrazole regioisomers in the development of nitro group-containing antitubercular agents

Tetrazole derivatives containing nitro substituents have been identified as promising antitubercular agents. In this study, the antitubercular potency, selectivity and toxicity of tetrazole 1,5- and 2,5-regioisomers were examined. We prepared a series of 1- and 2-alkyl-5-benzylsulfanyl-2H-tetrazoles and their selenium analogs with various nitro group substitutions. These 1,5- and 2,5-regioisomers were isolated and unambiguously identified using 1H and/or 13C NMR. Among the prepared compounds, 1- and 2-alkyl-5-[(3,5-dinitrobenzyl)sulfanyl]-2H-tetrazole derivatives and their selenium bioisosteres showed the highest antimycobacterial activity, with minimal inhibitory concentration (MIC) values of approximately 1 μM (0.37-0.46 μg mL-1) against Mycobacterium tuberculosis CNCTC My 331/88. The 2-alkyl regioisomers exhibited consistently higher antimycobacterial activity and lower in vitro toxicity against a mammalian cell line compared to the 1-alkyl isomers. The antimycobacterial activity of the 2-alkyl regioisomers was less influenced by the type of alkyl substituent in contrast to 1-alkyl isomers. Furthermore, the 3,5-dinitrobenzyl moiety per se is not the carrier of mutagenicity. These findings encourage further optimization of the 2-alkyl chain to improve the pharmacokinetic properties and toxicity of 2-alkyl-5-[(3,5-dinitrobenzyl)sulfanyl]-2H-tetrazole lead compounds. This journal is

Synthesis and Cycloaddition Reactivity of Selenoaldehydes

A variety of substituted selenoaldehydes has been prepared via fluoride desilylation of α-silyl selenocyanates or base-induced elimination of HCN from simple selenocyanates containing electron-accepting or conjugating substituents.Cycloaddition reactions