116809-20-2

Basic information

• Product Name: Benzeneethanol, a-methyl-, propanoate, (R)-
• CAS NO: 116809-20-2
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol File: 116809-20-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzeneethanol, a-methyl-, propanoate, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, a-methyl-, propanoate, (R)-(116809-20-2)
• EPA Substance Registry System: Benzeneethanol, a-methyl-, propanoate, (R)-(116809-20-2)

Safety Data

• Hazardous Substances Data: 116809-20-2(Hazardous Substances Data)

Upstream product

• 105-38-4 vinyl propionate 
• 698-87-3 3-phenyl-2-propanol 
• 123-62-6 propionic acid anhydride 
• 157752-41-5 rac-1-phenyl-2-propyl-propionate 

Downstream Products

• 1572-95-8 (R)-1-phenyl-propan-2-ol 

Relevant articles and documents

Acylative Kinetic Resolution of Alcohols Using a Recyclable Polymer-Supported Isothiourea Catalyst in Batch and Flow

A polystyrene-supported isothiourea catalyst, based on the homogeneous catalyst HyperBTM, has been prepared and used for the acylative kinetic resolution of secondary alcohols. A wide range of alcohols, including benzylic, allylic, and propargylic alcohols, cycloalkanol derivatives, and a 1,2-diol, has been resolved using either propionic or isobutyric anhydride with good to excellent selectivity factors obtained (28 examples, s values up to 600). The catalyst can be recovered and reused by a simple filtration and washing sequence, with no special precautions needed. The recyclability of the catalyst was demonstrated (15 cycles) with no significant loss in either activity or selectivity. The recyclable catalyst was also used for the sequential resolution of 10 different alcohols using different anhydrides with no cross-contamination between cycles. Finally, successful application in a continuous flow process demonstrated the first example of an immobilized Lewis base catalyst used for the kinetic resolution of alcohols in flow.

Homobenzotetramisole: An effective catalyst for kinetic resolution of aryl-cycloalkanols

Homobenzotetramisole (HBTM), a ring-expanded analogue of the previously reported catalyst BTM, displays higher catalytic activity and a different structure-selectivity profile. It displays good enantioselectivities in kinetic resolution of secondary benzylic alcohols but is particularly effective for 2-aryl-substituted cycloalkanols.

Activity enhancement of pig liver esterase in organic solvents by colyophilization with methoxypolyethylene glycol: Kinetic resolution of alcohols

Colyophilization of pig liver esterase with methoxypolyethylene glycol gave a catalyst, PLE/MPEG, which showed an enhanced activity in organic solvents. The PLE/MPEG catalyzed transesterification of the alcohols rac-1a- d with vinyl propionate in toluene proceeded with good to high selectivities. The addition of up to 1% of water to the reaction mixture resulted in a significant increase in enantioselectivity. Immobilization of PLE/MPEG for the batch-wise resolution was accomplished by its spontaneous adsorption on an ultrafiltration membrane.