116818-67-8

Basic information

• Product Name: 1-methyl-4-(4-phenylpiperidin-1-yl)carbonylpiperazine
• CAS NO: 116818-67-8
• Molecular Weight: 287.405
• Mol File: 116818-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-(4-phenylpiperidin-1-yl)carbonylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-(4-phenylpiperidin-1-yl)carbonylpiperazine(116818-67-8)
• EPA Substance Registry System: 1-methyl-4-(4-phenylpiperidin-1-yl)carbonylpiperazine(116818-67-8)

Safety Data

• Hazardous Substances Data: 116818-67-8(Hazardous Substances Data)

Upstream product

• 771-99-3 4-phenylpiperidine 
• 55112-42-0 4-methylpiperazine-1-carbonyl chloride monohydrochloride 
• 109-01-3 1-methyl-piperazine 

Relevant articles and documents

Studies in Potential Filaricides: Part 19 - Synthesis of 1-Methyl-4-substituted Carbonylpiperazines as Diethylcarbamazine Analogs

The synthesis and antifilarial activity of a series of 1-methyl-4-substituted carbamoyl- and carbonylpiperazines (6 - 42) against Litomosoides carinii in cotton rats and Dipetalonema viteae in Mastomys natalensis are described.The most potent compound of this series, 1-methyl-4-(pyrrolidin-1-yl)carbonylpiperazine (7) causes 95 - 98 percent reduction of blood microfilarial count in cotton rats infected with L. carinii at an intraperitoneal or oral dose of 1.5 (base) or 3 (citrate) mg/kg given for 6 days.A number of other compounds also exhibit marked microfilaricidal efffect in the dose range of 6 - 30 mg/kg.