116836-61-4

Basic information

• Product Name: trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester
• CAS NO: 116836-61-4
• Molecular Weight: 277.32
• Mol File: 116836-61-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester(116836-61-4)
• EPA Substance Registry System: trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester(116836-61-4)

Safety Data

• Hazardous Substances Data: 116836-61-4(Hazardous Substances Data)

Upstream product

• 124-04-9 Adipic acid 
• 868-72-4 dimethyl (2R,5S)-2,5-dibromohexanedioate 
• 100-46-9 benzylamine 
• 29548-86-5 2,5-dibromohexanedioyl dichloride 
• 868-72-4 dimethyl 2,5-dibromohexanedioate 
• 111-50-2 Adipic acid dichloride 
• 868-72-4 dimethyl rac-2,5-dibromohexanedioate 
• 102508-03-2 cis-2,5-dimethyl N-benzylpyrrolidine-2,5-dicarboxylate 
• 51483-87-5 1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester 

Downstream Products

• 727351-54-4 rac-(2S,5R)-5-fluoro-2-piperidinecarboxylic acid 
• 118335-80-1 trans-1-<2-Chlor-3-(phenylthio)propionyl>-2,5-pyrrolidindicarbonsaeure-dimethylester 
• 157008-40-7 trans-N-benzyl-2,5-bis(hydroxymethyl)pyrrolidine 
• 154004-77-0 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 154004-76-9 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 154004-75-8 (2R,5R)-5-{[(R)-1-Benzyloxycarbonyl-2-(1H-indol-3-yl)-ethylamino]-methyl}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 153908-38-4 (2S,5S)-5-{[(R)-1-Benzyloxycarbonyl-2-(1H-indol-3-yl)-ethylamino]-methyl}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant articles and documents

A mechanochemical approach to access the proline-proline diketopiperazine framework

Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline-proline dipeptides under solvent-free conditions. A deprotection-cyclization sequence yielded the corresponding diketopiperazines that were obtained with a high stereoselectivity which could be explained by DFT calculations. Using this method, an enantiopure disubstituted Pro-Pro diketopiperazine was synthesized in 4 steps, making 5 new bonds using a ball mill.

Synthesis of both enantiomers of C2 symmetric trans-2,5- bis(hydroxymethyl)pyrrolidine. Lipase mediated sequential kinetic resolutions

Lipase mediated sequential kinetic resolution has been employed to give both enantiomers of trans-2,5-bis(hydroxymethyl)pyrrolidine in optically pure form. The effect of different parameters on the ee and yields in these resolutions are also reported.

Base-Catalysed Epimerization Behavior and Unusual Reactivity of N-Substituted Derivatives of 2,5-Dicarbalkoxypyrrolidine. Preparation of a Novel Mixed Carbamic Carbonic Anhydride by a 4-(Dimethylamino)pyridine-Catalyzed Acylation

The equilibration of cis-trans isomers of 1-substituted 2,5-dicarbalkoxypyrrolidine derivatives (1 = CH2Ph, H, CN, CO2R) results in nearly 1:1 mixtures, contrary to a literature report for 1-benzyl-2,5-dicarbalkoxypyrrolidine.Apparent conversion to the tr