727351-54-4

Upstream product

• 116836-61-4 trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester 
• 675605-34-2 Trifluoro-methanesulfonic acid (6S,8aS)-1-oxo-3,3-bis-trifluoromethyl-hexahydro-oxazolo[3,4-a]pyridin-6-yl ester 
• 675605-29-5 (S)-4-(4-Diazo-3-oxo-butyl)-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 675605-33-1 (6S,8aS)-6-Hydroxy-3,3-bis-trifluoromethyl-tetrahydro-oxazolo[3,4-a]pyridin-1-one 
• 675605-30-8 3,3-bis-trifluoromethyl-dihydro-oxazolo[3,4-a]pyridine-1,6-dione 
• 131021-88-0 (S)-[2,2-bis(trifluoromethyl)-5-oxo-1,3-oxazolidin-4-yl]propionic acid 
• 56-86-0 L-glutamic acid 
• 675605-35-3 (6R,8aS)-6-Fluoro-3,3-bis-trifluoromethyl-tetrahydro-oxazolo[3,4-a]pyridin-1-one 

Relevant academic research and scientific papers

Exploiting morph-DAST mediated ring-expansion of substituted cyclic β-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5-fluoromethylproline and 5-fluoropipecolic acid

The synthesis of proline analogues bearing a fluorine-containing substituent at the fifth position of the pyrrolidine ring, racemic trans- and cis-5-fluoromethyl prolines, was performed. The key step of the synthesis is a transformation of the CH2/s

Hexafluoroacetone as a protecting and activating reagent: 5,5-difluoro- and trans-5-fluoropipecolic acids from glutamic acid

Starting from hexafluoroacetone-protected (S)-glutamic acid, trans-5-fluoropipecolic and 5,5-difluoropipecolic acid have been synthesized. The piperidine ring was constructed by an intramolecular metal carbenoid NH insertion.