116858-57-2

Basic information

• Product Name: 3-Ethoxy-2-phenyl-2-piperidin-1-yl-but-3-enenitrile
• Synonyms: 3-Ethoxy-2-phenyl-2-piperidin-1-yl-but-3-enenitrile
• CAS NO: 116858-57-2
• Molecular Weight: 270.374
• Mol File: 116858-57-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Ethoxy-2-phenyl-2-piperidin-1-yl-but-3-enenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethoxy-2-phenyl-2-piperidin-1-yl-but-3-enenitrile(116858-57-2)
• EPA Substance Registry System: 3-Ethoxy-2-phenyl-2-piperidin-1-yl-but-3-enenitrile(116858-57-2)

Safety Data

• Hazardous Substances Data: 116858-57-2(Hazardous Substances Data)

Upstream product

• 5766-79-0 2-phenyl-2-piperidinoacetonitrile 
• 927-80-0 1-ethoxyacetylene 

Relevant articles and documents

Reactions of 2-(Dialkylamino)arylacetonitriles with Acetylenes Under Basic Conditions. A Simple Synthesis of Substituted Mono and Diketones

2-(Dialkylamino)arylacetonitriles 1 react with acetylenes 2a,b in dimethyl sulfoxide, powdered sodium hydroxide and triethylbenzylammonium chloride as a catalyst to give 3 and/or 4.The latter are formed via addition of anion 8 to immonium salt 9.The type of product formed depends on the basicity of amino moiety in 3.Furthermore, compound 1 adds to C-1 of acetylene 2c affording the vinyl derivatives 15.The products 3,4,11 and 15 are hydrolyzed to give ketones 5-7,12 and 16, respectively.