5766-79-0

Basic information

• Product Name: 2-PHENYL-2-PIPERIDINOACETONITRILE
• Synonyms: LABOTEST-BB LT00454898;2-PHENYL-2-PIPERIDINOACETONITRILE;1-(1-Cyanobenzyl)piperidine;1-(a-Cyanobenzyl)-piperidine;2-phenyl-2-piperidino-acetonitril;Acetonitrile, 2-phenyl-2-piperidino-;alpha-(1-Piperidyl)-alpha-tolunitrile;alpha-phenyl-1-piperidineacetonitril
• CAS NO: 5766-79-0
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 200.28
• EINECS: 227-291-9
• Mol File: 5766-79-0.mol
• Article Data: 37

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 296.1°Cat760mmHg
• Flash Point: 118.1°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 2-PHENYL-2-PIPERIDINOACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2-PIPERIDINOACETONITRILE(5766-79-0)
• EPA Substance Registry System: 2-PHENYL-2-PIPERIDINOACETONITRILE(5766-79-0)

Safety Data

• Hazardous Substances Data: 5766-79-0(Hazardous Substances Data)

Usage

Uses

Phenylpiperidinoacetonitrile, is a building block used in various chemical synthesis.

InChI:InChI=1/C13H16N2/c14-11-13(12-7-3-1-4-8-12)15-9-5-2-6-10-15/h1,3-4,7-8,13H,2,5-6,9-10H2

Upstream product

• 110-89-4 piperidine 
• 100-52-7 benzaldehyde 
• 151-50-8 potassium cyanide 
• 6091-44-7 piperidine hydrochloride 
• 7677-24-9 trimethylsilyl cyanide 
• 3010-03-5 piperidin-1-yl-acetonitrile 
• 108-90-7 chlorobenzene 
• 776-75-0 N-benzoylpiperidine 
• 98-88-4 benzoyl chloride 
• 108-88-3 toluene 
• 2591-86-8 N-Formylpiperidine 
• 100-58-3 phenylmagnesium bromide 
• 532-28-5 (RS)-mandelonitrile 
• 78-67-1 2,2'-azobis(isobutyronitrile) 

Downstream Products

• 40419-16-7 1-(1,3-diphenyl-propyl)-piperidine 
• 110244-51-4 1-(1,4-diphenyl-butyl)-piperidine 
• 98065-14-6 1-(1-phenyl-propyl)-piperidine 
• 101266-22-2 phenyl-piperidino-thioacetic acid amide 
• 7253-67-0 (R,S)-1-(1-piperidino)phenylacetamide 
• 64-04-0 phenethylamine 
• 107416-50-2 2-phenyl-2-(piperidin-1-yl)acetic acid hydrochloride 
• 72219-09-1 1-benzylpyrrolidine-2-carbonitrile 
• 1025-56-5 N-benzyl-2-phenyl-pyrrolidine 
• 1260380-74-2 1-benzyl-2-butylpyrrolidine 
• 479-81-2 AU₂₁₁₀₆ 
• 107416-49-9 phenyl(piperidin-1-yl)acetic acid 
• 495-71-6 phenacylacetophenone 
• 128407-57-8 2-Methylsulfanyl-4-phenyl-1-p-tolyl-butane-1,4-dione 

Relevant articles and documents

A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

One-Pot Synthesis of α-Amino Nitrile Units through Alkylative Strecker Cyanation from Formamides

In this work, we describe the one-pot synthesis of α-amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in sco

Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.