116869-00-2

Upstream product

• 116868-98-5 2,2-bis(4'-nitrophenyl)ethan-1-ol 
• 76-02-8 trifluoroacetyl chloride 
• 96-09-3 styrene oxide 
• 108-86-1 bromobenzene 
• 116868-97-4 2,2-bis(4'-nitrophenyl)ethyl acetate 
• 6319-82-0 ethyl 2,2-diphenylacetate 
• 1883-32-5 2,2-diphenyl ethanol 
• 75-44-5 phosgene 

Downstream Products

• 116869-01-3 2,2-bis(4'-nitrophenyl)ethyl-N-succinimidyl carbonate 
• 125836-09-1 3-carboethoxy-1-<2',2'-bis-(4-nitrophenyl)ethoxycarbonyl>-1,4-dihydroquinolin-4-one 
• 138296-25-0 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-α-aminoisobutyric acid 
• 138296-23-8 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^ε-(tert-butyloxycarbonyl)-lysine 
• 138296-33-0 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-(γ-tert-butyl)glutamic acid 
• 138296-29-4 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-β-(tert-butyl)aspartic acid 
• 138296-47-6 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-(O-tert-butyl)threonine 
• 138296-44-3 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-(O-tert-butyl)serine 
• 138296-37-4 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-isoleucine 
• 138296-39-6 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-methionine 
• 137043-71-1 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)arginine 
• 138296-32-9 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine 
• 138296-28-3 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-bis(4'-methoxyphenyl)methylasparagine 
• 138296-49-8 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-tryptophan 

Relevant academic research and scientific papers

Nucleosides. Part LXIV. Base-Labile Protecting Groups for the Oligoribonucleotide Synthesis

New labile protecting groups for the anticipated synthesis of oligoribonucleotides were developed and introduced via their carbonochloridates 8-11 at the 5'-O position of thymidine (15) to form 16, 18, 21, and 24 in good yields (Schemes 2 and 3). Similarly, the 5'-O-diphenylphosphinoyl(dpp)-protected thymidine derivative 27 was synthesized with diphenylphosphinoyl chloride 14 as the reactive reagent. With the help of the model compounds 16, 18, 21, 24, and 27, the deprotection rates of these functions towards base treatment were recorded to evaluate their usefulness as temporary protecting groups in RNA assembly (Table). Finally, the relative stability of the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) protecting group towards bases confirmed its use as a permanent blocking group in our npe/npeoc strategy.

A base labile protecting group for peptide synthesis: 2,2,-Bis(4'-nitrophenyl)ethan-1-oxycarbonyl urethanes

A base labile urethane (Bnpeoc) group derived from 2,2,-bis(4'-nitrophenyl)ethan-1-ol has been developed as an amine protecting group. This protecting group may be cleaved using the reagents DBN, DBU, DBU/HOAc and piperidine. The preparations of N(α)-Bnpeoc amino acids and applications to peptide/glycopeptide synthesis are described.