116912-15-3 Usage
Uses
Used in Medicinal Chemistry:
L-Leucine, N-[N-(phenylacetyl)-L-phenylalanyl]-, 2-propenyl ester is used as a protease inhibitor for its potential biological activity, which may contribute to the development of new therapeutic agents.
Used in Cancer Therapy:
L-Leucine, N-[N-(phenylacetyl)-L-phenylalanyl]-, 2-propenyl ester is being studied as a potential therapeutic agent for cancer treatment, with the aim of inhibiting proteases that play a role in tumor growth and progression.
Used in Neurodegenerative Disease Treatment:
L-Leucine, N-[N-(phenylacetyl)-L-phenylalanyl]-, 2-propenyl ester is being investigated for its potential to treat neurodegenerative diseases, possibly through its protease inhibitory effects, which could help slow the progression of these conditions.
Used in Drug Delivery Systems:
L-Leucine, N-[N-(phenylacetyl)-L-phenylalanyl]-, 2-propenyl ester may also have applications in the field of drug delivery, where it could be used to improve the efficacy and bioavailability of other therapeutic agents, potentially enhancing their performance in treating various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 116912-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,9,1 and 2 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 116912-15:
(8*1)+(7*1)+(6*6)+(5*9)+(4*1)+(3*2)+(2*1)+(1*5)=113
113 % 10 = 3
So 116912-15-3 is a valid CAS Registry Number.
116912-15-3Relevant articles and documents
The Phenylacetyl (PhAc) Group as Enzymatically Removable Protecting Function for Peptides and Carbohydrates: Selective Deprotections with Penicillin Acylase
Waldmann, Herbert
, p. 1175 - 1180 (2007/10/02)
Using the modified carbodiimide procedure or EEDQ as coupling reagent, N-Phenylacetyl (PhAc) amino acids are condensed in good yields with amino acid methyl, benzyl, allyl, and tert-butyl esters to give totally protected dipeptides.The PhAc group is stabl
THE USE OF PENICILLIN ACYLASE FOR SELECTIVE N-TERMINAL DEPROTECTION IN PEPTIDE SYNTHESIS
Waldmann, Herbert
, p. 1131 - 1134 (2007/10/02)
Penicillin acylase from E. coli (EC 3.5.1.11) accepts a broad range of N-phenylacetyl-dipeptide esters as substrates.The enzyme hydrolyses the N-terminal protecting group selectively at room temp. and pH=8.1 without affecting the peptide- or the ester-bonds.Alternatively methyl-, benzyl-, tert-butyl and allyl esters can be cleaved chemically leaving the phenylacetamido moiety intact.
