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738-75-0

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738-75-0 Usage

General Description

N-(Phenylacetyl)-L-phenylalanine, also known as N-phenylacetyl-L-phenylalanine or NPP, is a chemical compound classified as an opioid analgesic. It is a relatively potent and selective agonist for the μ-opioid receptor, which is the primary target for most clinically-relevant opioid analgesics. NPP has been studied for its potential use in pain management and has shown promising results in preclinical trials. However, due to its structural similarity to other opioids such as fentanyl and sufentanil, NPP may also have potential for abuse and dependence. As a result, research on NPP is ongoing to better understand its therapeutic potential and potential risks if utilized as a pharmaceutical drug.

Check Digit Verification of cas no

The CAS Registry Mumber 738-75-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,3 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 738-75:
(5*7)+(4*3)+(3*8)+(2*7)+(1*5)=90
90 % 10 = 0
So 738-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H17NO3/c19-16(12-14-9-5-2-6-10-14)18-15(17(20)21)11-13-7-3-1-4-8-13/h1-10,15H,11-12H2,(H,18,19)(H,20,21)/t15-/m0/s1

738-75-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-3-phenyl-2-[(2-phenylacetyl)amino]propanoic acid

1.2 Other means of identification

Product number -
Other names N-phenylacetyl-L-phenylalanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:738-75-0 SDS

738-75-0Relevant articles and documents

GRANZYME B DIRECTED IMAGING AND THERAPY

-

Page/Page column 82; 97, (2019/09/04)

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Intramolecular interactions of a phenyl/perfluorophenyl pair in the formation of supramolecular nanofibers and hydrogels

Hsu, Shu-Min,Lin, Yu-Chun,Chang, Jui-Wen,Liu, Yu-Hao,Lin, Hsin-Chieh

supporting information, p. 1921 - 1927 (2014/03/21)

A new system for the incorporation of a phenyl/perfluorophenyl pair in the structure of a peptide hydrogelator was developed. The strategy is based on the idea that the integration of an end-capped perfluorophenyl group and a phenylalanine with a phenyl moiety in the side chain forms an intramolecular phenyl/perfluorophenyl pair, which can be used to promote the formation of the supramolecular nanofibers and hydrogels. This work illustrates the importance of structure-hydrogelation relationship and provides new insights into the design of self-assembly nanobiomaterials. Intramolecular binding: The incorporation of a phenyl/perfluorophenyl pair into the structure of a peptide hydrogelator leads to the formation of the supramolecular nanofibers. The quadrupole-dipole- quadrupole (q-d-q) interactions between the aromatic rings facilitate self-assembly. This work illustrates the importance of the structure- hydrogelation relationship and provides new insights into the design of self-assembled nanobiomaterials. Copyright

Alcaligenes faecalis penicillin G acylase-catalyzed enantioselective acylation of dl-phenylalanine and derivatives in aqueous medium

Gong, Xiangyu,Su, Erzheng,Wang, Pixiang,Wei, Dongzhi

supporting information; experimental part, p. 5398 - 5402 (2011/10/19)

A new strategy based on enantioselective acylation properties of relatively unknown penicillin G acylase from Alcaligenes faecalis has been developed for the production of pharmacologically interesting enantiomerically pure d-phenylalanine. In order to get high reaction rate and enantioselectivity, two key factors (pH and temperature) and eight different acyl donors were optimized, and the optimal acylation reaction was carried out at pH 10, 35 °C, using phenylacetamide as the acyl donor. This enantioselective acylating method is also illustrated by the effective production of five different p-substituted phenylalanine derivatives in enantiopure.

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