116922-61-3 Usage
Description
4-Fluoro-3-(trimethylsilyl)pyridine, a pyridine derivative with the molecular formula C8H11FNSi, is a chemical compound that features a fluorine atom and a trimethylsilyl group. It is known for its reactivity and is commonly utilized in various organic synthesis processes, particularly for the formation of carbon-carbon and carbon-nitrogen bonds. Additionally, it serves as a protecting group in the synthesis of complex organic molecules. 4-FLUORO-3-(TRIMETHYLSILYL)PYRIDINE's potential extends to the pharmaceutical and agrochemical industries, where it aids in the synthesis of biologically active compounds. Due to its reactive nature, careful handling and storage are essential to prevent accidents or exposure to harmful effects.
Uses
Used in Organic Synthesis:
4-Fluoro-3-(trimethylsilyl)pyridine is used as a reagent in organic synthesis for the formation of carbon-carbon and carbon-nitrogen bonds, which are crucial in creating a wide range of organic compounds.
Used as a Protecting Group in Organic Synthesis:
In the synthesis of complex organic molecules, 4-fluoro-3-(trimethylsilyl)pyridine serves as a protecting group, which is essential for preventing unwanted reactions during the synthesis process.
Used in Pharmaceutical Industry:
4-Fluoro-3-(trimethylsilyl)pyridine is utilized in the pharmaceutical industry for its role in facilitating the synthesis of biologically active compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, this compound is applied to aid in the synthesis of biologically active compounds, potentially leading to the creation of new pesticides, herbicides, or other agrochemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 116922-61-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,9,2 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 116922-61:
(8*1)+(7*1)+(6*6)+(5*9)+(4*2)+(3*2)+(2*6)+(1*1)=123
123 % 10 = 3
So 116922-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H12FNSi/c1-11(2,3)8-6-10-5-4-7(8)9/h4-6H,1-3H3
116922-61-3Relevant articles and documents
Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis
Marsais, F.,Trecourt, F.,Breant, P.,Queguiner, G.
, p. 81 - 87 (2007/10/02)
4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.
