116922-73-7

Basic information

• Product Name: ETHANONE,1-(4-CHLORO-3-PYRIDINYL)-
• Synonyms: ETHANONE,1-(4-CHLORO-3-PYRIDINYL)-;1-(4-chloropyridin-3-yl)ethan-1-one;1-(4-chloro-3-pyridinyl)Ethanone;1-(4-chloropyridin-3-yl)ethanone
• CAS NO: 116922-73-7
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Mol File: 116922-73-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: ETHANONE,1-(4-CHLORO-3-PYRIDINYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: ETHANONE,1-(4-CHLORO-3-PYRIDINYL)-(116922-73-7)
• EPA Substance Registry System: ETHANONE,1-(4-CHLORO-3-PYRIDINYL)-(116922-73-7)

Safety Data

• Hazardous Substances Data: 116922-73-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHANONE,1-(4-CHLORO-3-PYRIDINYL)is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs, contributing to the advancement of medical treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, ETHANONE,1-(4-CHLORO-3-PYRIDINYL)serves as an intermediate in the production of agrochemicals. Its incorporation in the synthesis process helps create effective solutions for agricultural applications, such as pesticides and herbicides, to protect crops and enhance agricultural productivity.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 89284-61-7 4-chloro-nicotinonitrile 
• 116922-69-1 rac-4-chloro-3-(1-hydroxyethyl)pyridine 
• 626-61-9 4-Chloropyridine 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 191725-82-3 1-(4-methoxypyridin-3-yl)ethanone 

Relevant articles and documents

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4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.