116939-86-7

Basic information

• Product Name: Z-Leu-Pro-OH . CHA
• Synonyms: Z-Leu-Pro-OH . CHA
• CAS NO: 116939-86-7
• Molecular Formula: C₁₉H₂₆N₂O₅
• Molecular Weight: 362.42014
• Mol File: 116939-86-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Z-Leu-Pro-OH . CHA(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Leu-Pro-OH . CHA(116939-86-7)
• EPA Substance Registry System: Z-Leu-Pro-OH . CHA(116939-86-7)

Safety Data

• Hazardous Substances Data: 116939-86-7(Hazardous Substances Data)

Upstream product

• 49761-04-8 N-(benzyloxycarbonyl)-L-leucyl-L-proline methyl ester 
• 2018-66-8 N-(Benzyloxycarbonyl)-L-leucine 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 49761-04-8 (S)-1-(2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 2018-66-8 2-Benzyloxycarbonylamino-4-methyl-pentanoic acid 
• 49761-04-8 (S)-1-(2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 147-85-3 L-proline 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 2018-66-8 Z-Leu-OH 

Downstream Products

• 220657-16-9 (S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester 
• 220657-18-1 (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 1380332-71-7 Cbz-(L)-leucyl-(L)-prolyl benzotriazole 
• 2873-36-1 (3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 1380332-79-5 cyclo(Z-L-Leu-D-Pro) 
• 126587-62-0 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4- 
• 126587-64-2 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2- 
• 1053630-19-5 C₆₆H₁₀₇N₅O₁₆Si 
• 126587-63-1 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop 
• 148339-15-5 C₅₈H₁₀₁N₅O₁₅Si 
• 126587-61-9 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine-OSEM 
• 129919-84-2 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine 
• 2873-36-1 cyclo(L-Pro-L-Leu) 
• 138541-24-9 H-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH 

Relevant articles and documents

MALT1 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

Total synthesis and biological evaluation of tamandarin B analogues

(Chemical Equation Presented) Tamandarins A and B are a class of marine natural cyclodepsipeptides with structures and biological activities closely related to those of the didemnins. The easier synthetic access to tamandarins accelerates the preparation of new macrocyclic derivatives of this family of antitumor, antiviral, and immunosuppressive compounds. The optimization of the previously reported synthetic route to tamandarins by changing the macrolactamization site from Nst1 and Thr6 to Pro 4 and N,O-Me2Tyr5 residues led to a significant improvement in the reaction yield. Using this new synthetic approach, four new macrocyclic analogues of tamandarin B were prepared and evaluated for anticancer activity. These results provide further insight into the structure-activity relationship of the tamandarins and didemnins.

Total Synthesis of Thymosin β4, 2. Conventional Synthesis of the Fragment of Thymosin β4

As part of the total synthesis of thymosin β4 three synthetic pathways for the synthesis of the thymosin β4 fragment are described.The side-chain functions are protected by tert-butyl and the α-amino residues by Z groups.As temporary protection of the carboxyl function the phenyl ester is successfully used.Key Words: Thymosin β4, fragment /Thymus peptides/Amino acids/Protecting groups, phenyl esters of peptides as/Peptides