1169568-06-2Relevant academic research and scientific papers
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model
Yue, Eddy W.,Douty, Brent,Wayland, Brian,Bower, Michael,Liu, Xiangdong,Leffet, Lynn,Wang, Qian,Bowman, Kevin J.,Hansbury, Michael J.,Liu, Changnian,Wei, Min,Li, Yanlong,Wynn, Richard,Burn, Timothy C.,Koblish, Holly K.,Fridman, Jordan S.,Metcalf, Brian,Scherle, Peggy A.,Combs, Andrew P.
, p. 7364 - 7367 (2009)
A hydroxyamidine chemotype has been discovered as a key pharmacophore in novel inhibitors of indoleamine 2,3-dioxygenase (IDO). Optimization led to the identification of 5l, which is a potent (HeLa IC50=19 nM) competitive inhibitor of IDO. Testing of 5l i
