1169699-64-2

Usage

Uses

Used in Organic Chemistry Research:
9-Benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one is utilized as a research compound for the study of its chemical properties and potential applications in the field of organic chemistry. Its complex structure makes it a subject of interest for scientists exploring new chemical reactions and synthesis pathways.
Used in Pharmaceutical Research:
Although not widely published, 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one may also be used as a starting material or intermediate in the development of new pharmaceutical compounds. Its unique structure could potentially offer novel therapeutic properties, warranting further investigation in drug discovery and design.
Used in Chemical Synthesis:
In the chemical industry, 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one could be employed as a building block or intermediate in the synthesis of more complex molecules. Its reactivity and functional groups may be exploited to create new compounds with specific properties or applications.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 23804-68-4 4-(aminomethyl)-1-benzyl-4-hydroxypiperidine 
• 19867-34-6 N-benzyl-1-oxa-6-azaspiro[2,5]-octane 
• 1169699-63-1 N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide 

Downstream Products

• 1023595-11-0 tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate 

Relevant academic research and scientific papers

Spirocyclic derivatives

The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R5, R6, R9, R10, Q, X, Y, Z, A, L, B, m, n and p are as defined herein.

2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD)

The present invention provides compounds of formula (I) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7- diazaspiro[4.5]decan-10-one derivatives and related compounds as inhibitors of human dopamine-active-transporter (DAT) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, chronic fatigue, Tourette syndrome, Angelman syndrome, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), obesity, pain, obsessive-compulsive disorder, movement disorders, CNS disorders, sleep disorders, narcolepsy, conduct disorder, substance abuse (including smoking cessation), eating disorders, and impulse control disorders.

ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.