1169855-54-2

Upstream product

• 50-00-0 formaldehyd 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1169855-94-0 C₂₁H₂₀ClN₃O₄ 
• 1169855-87-1 C₂₁H₂₀ClN₃O₄ 
• 1378941-89-9 (1R,6S,7S,8S)-8-(4-chlorophenyl)-1-nitro-7-phenyl-3-oxabicyclo[4.2.0]octan-4-one 
• 1378941-90-2 (1R,6S,7S,8S)-8-(4-chlorophenyl)-1-nitro-7-(p-tolyl)-3-oxabicyclo[4.2.0]octan-4-one 
• 1420881-91-9 (3aS,4S,8R,9R,9aS)-8-benzoyl-9-(4-chlorophenyl)-4-phenyltetrahydrofuro[3,4-c]isoxazolo[2,3-b]isoxazolo-3(1H)-one 

Relevant academic research and scientific papers

Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3 + 3] annulation of quinolinones and MBH 2-naphthoates of nitroolefin

An efficient asymmetric and enantio-swithchable organocatalytic [3 + 3] annulation reaction using MBH-2-naphthoates of nitroalkenes and 4-hydroxyquinolin-2(1H)-ones has been developed. Densely substituted tetrahydropyrano[3,2-c]quinolinones scaffolds with two adjacent stereogenic centers are obtained with high yield (up to 95% yield) and good stereoselectivities (up to >20:1 dr and 96% ee) in an enantio-switchable manner. Furthermore, gram scale synthesis was achieved and the nitro group could easily transform into an amino group without any appreciable loss in the diastereo- and enantioselectivity.

Stereoselective Synthesis of 3-Oxabicyclo[3.3.1]Nonan-2-Ones via a Domino Reaction Catalyzed by Modularly Designed Organocatalysts

A highly stereoselective method for the synthesis of functionalized 3-oxabicyclo[3.3.1]nonan-2-one derivatives with four contiguous stereogenic centers, including one tetrasubstituted stereogenic center, was realized through an organocatalytic domino Mich

Enantioselective construction of oxa- and aza-angular triquinanes through tandem [4 + 1]/[3 + 2] cycloaddition of sulfur ylides and nitroolefins

A formal [4 + 1]/[3 + 2] cycloaddition sequence of sulfur ylides and alkene-tethered nitroolefins has been developed. The use of (R)-binol-derived chiral sulfide leads to an asymmetric process that allows the construction of oxa- and aza-angular triquinanes in good to excellent diastereo- and enantioselectivities.

Cooperative dienamine/hydrogen-bonding catalysis: Enantioselective formal [2+2] cycloaddition of enals with nitroalkenes

Two can play this game: The title reaction is catalyzed by a chiral secondary amine in the presence of an achiral thiourea for the enantio- and diastereoselective synthesis of highly functionalized cyclobutanes (see scheme; TMS=trimethylsilyl). Mechanistically, two consecutive Michael reactions proceed through an unprecedented combination of an dienamine/iminium activation mode. Copyright

1,3-dipolar cycloaddition on baylis-hillman adducts: Novel synthesis of pyrrolidines, spiropyrrolidines, and spiropyrrolizidines

A facile regio- and stereoselective synthesis of functionalized pyrrolidines, spiropyrrolidines, and spiropyrrolizidines using the Baylis-Hillman adducts derived from nitroolefins via intermolecular [3+2]-cycloaddition reaction is reported. Georg Thieme Verlag Stuttgart ? New York.