1169867-99-5

Upstream product

• 42472-69-5 4-ethynylacetophenone 
• 7154-66-7 2-bromobenzoic acid chloride 
• 615-36-1 2-bromoaniline 
• 201230-82-2 carbon monoxide 
• 1319750-41-8 1-(2-bromophenyl)-3,3-diethyltriaz-1-ene 

Downstream Products

• 1169867-68-8 (Z)-3-(4-acetylphenyl)-1-(2-bromophenyl)-3-(4-chloroanilino)prop-2-en-1-one 
• 1169867-70-2 (Z)-3-(4-acetylphenyl)-1-(2-bromophenyl)-3-(4-methoxyanilino)-prop-2-en-1-one 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylative Sonogashira coupling between aryl triazenes and alkynes

We developed a palladium-catalyzed carbonylative Sonogashira reaction with aryl triazenes and alkynes as substrates and methanesulfonic acid as the additive. A series of α,β-ynones were synthesized by this alternative procedure. Notably, bromides, iodides

1,2-Disubstituted 4-quinolones via copper-catalyzed cyclization of 1-(2-halophenyl)-2-en-3-amin-1-ones

1,2-Disubstituted 4-quinolones have been prepared via copper-catalyzed heterocyclization of 1-(2-bromophenyl)- and 1-(2-chlorophenyl)-2-en-3-amin-1- ones, readily obtained from α,β-ynones and primary amines. The reaction tolerates a variety of useful functionalities including ester, keto, cyano, and chloro substituents. Quinolone derivatives can also be prepared via a sequential process from α,β-ynones and primary amines, omitting the isolation of the 1-(2-halophenyl)-2-en-3-amin-1-one intermediates. Georg Thieme Verlag Stuttgart.