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C17H27N4O4S(1-)K(1+), also known as Cobicistat, is a chemical compound used in the pharmaceutical industry. It is a potent and selective inhibitor of the cytochrome P450 3A (CYP3A) enzyme, which is involved in the metabolism of various drugs. Cobicistat is often used in combination with other medications to enhance their efficacy and reduce the frequency of dosing.

1169870-16-9

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1169870-16-9 Usage

Uses

Used in Pharmaceutical Industry:
C17H27N4O4S(1-)K(1+) is used as a pharmacokinetic enhancer for improving the absorption and bioavailability of co-administered medications, particularly in the treatment of HIV.
Used in HIV Treatment:
C17H27N4O4S(1-)K(1+) is used as a booster for antiretroviral drugs in the treatment of HIV. It helps to increase the concentration and effectiveness of the primary drug, allowing for lower doses and less frequent dosing, which can improve patient adherence to the treatment regimen.
Used in Drug Synthesis:
C17H27N4O4S(1-)K(1+) is used as a key component in the synthesis of various pharmaceutical compounds, contributing to the development of new medications with improved properties and therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1169870-16-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,9,8,7 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1169870-16:
(9*1)+(8*1)+(7*6)+(6*9)+(5*8)+(4*7)+(3*0)+(2*1)+(1*6)=189
189 % 10 = 9
So 1169870-16-9 is a valid CAS Registry Number.

1169870-16-9Relevant academic research and scientific papers

INHIBITORS OF CYTOCHROME P450

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Paragraph 0885; 0886, (2015/11/10)

The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

PROCESS FOR THE PREPARATION OF COBICISTAT INTERMEDIATES

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Page/Page column 5; 12, (2014/05/07)

The present invention relates to cobicistat intermediates, processes and further conversion to cobicistat with improved yield and quality.

METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS

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Page/Page column 22, (2010/10/19)

The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.

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