116993-94-3

Upstream product

• 42116-21-2 2-benzyloxycarbonylsulfanyl-4,6-dimethyl-pyrimidine 
• 2018-66-8 Z-Leu-OH 
• 77-76-9 2,2-dimethoxy-propane 
• 70853-26-8 N-carbobenzoxy-L-leucinal 
• 109075-73-2 benzyl (S)-[1-(N-methoxy-N-methylamino)-4-methyl-1-oxopentan-2-yl]carbamate 
• 116993-90-9 Methyl <(4S,5S)-3-Benzyloxycarbonyl-4-isobutyl-2,2-dimethyl-5-oxazolidinyl> Acetate 
• 93287-62-8 (3S,4S)-4-Benzyloxycarbonylamino-3-hydroxy-6-methyl-heptanoic acid methyl ester 
• 116993-91-0 Methyl (4S,5S)-3-Benzyloxycarbonyl-5-(2-hydroxyethyl)-4-isobutyl-2,2-dimethyloxazolidine 
• 93287-37-7 (3S,4S)-4-(carbamic acid benzyl ester)-3-hydroxy-6-methyl-heptanoic acid 
• 49642-07-1 statine 
• 116993-92-1 (4S,5S)-3-Benzyloxycarbonyl-5-(2-chloroethyl)-4-isobutyl-2,2-dimethyloxazolidine 

Downstream Products

• 116993-95-4 (4S,5S)-3-Benzyloxycarbonyl-5-formyl-4-isobutyl-2,2-dimethyloxazolidine 
• 130981-00-9 3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2-ethyl-2-propenoic acid 
• 118741-35-8 (4S,5S)-5-((E)-2-Ethoxycarbonyl-vinyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 130980-99-3 Ethyl 3-<(4S,5S)-3-benzyloxycarbonyl-4-isobutyl-2,2-dimethyl-5-oxazolidinyl>-2-ethyl-2-propenoate 
• 118586-17-7 (4S,5S)-5-((E)-2-Ethoxycarbonyl-3-methyl-but-1-enyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 130900-34-4 (4S,5S)-5-((E)-2-Ethoxycarbonyl-4-methyl-pent-1-enyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 130900-36-6 (4S,5S)-5-((E)-3-Cyclohexyl-2-ethoxycarbonyl-propenyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 130900-38-8 (4S,5S)-5-((E)-2-Ethoxycarbonyl-4-phenyl-but-1-enyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 118741-17-6 (2Z)-N-Isobutyl-3-<(4S,5S)-3-benzyloxycarbonyl-4-isobutyl-2,2-dimethyl-5-oxazolidinyl>-2-ethyl-2-propenamide 
• 118741-18-7 (2E)-N-Isobutyl-3-<(4S,5S)-3-benzyloxycarbonyl-4-isobutyl-2,2-dimethyl-5-oxazolidinyl>-2-ethyl-2-propenamide 

Relevant academic research and scientific papers

Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors

A superior substrate sequence for BACE1 containing transition-state mimics at the scissile site was evaluated as a protease inhibitor. Hydroxymethylcarbonyl (HMC) and hydroxyethylamine (HEA) isosteres were selected as the transition state mimics, and inco