1169969-36-1

Basic information

• Product Name: (2R,5S,6S,7R)-2',7'-dibromospiro[1-aza-7-ethoxycarbonyl-3-oxa-8-oxo-2-phenyltricyclo[4.3.0^1,5.0^6,7]nonane-9,9′-fluorene]
• CAS NO: 1169969-36-1
• Molecular Weight: 595.287
• Mol File: 1169969-36-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,5S,6S,7R)-2',7'-dibromospiro[1-aza-7-ethoxycarbonyl-3-oxa-8-oxo-2-phenyltricyclo[4.3.0^1,5.0^6,7]nonane-9,9′-fluorene](CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S,6S,7R)-2',7'-dibromospiro[1-aza-7-ethoxycarbonyl-3-oxa-8-oxo-2-phenyltricyclo[4.3.0^1,5.0^6,7]nonane-9,9′-fluorene](1169969-36-1)
• EPA Substance Registry System: (2R,5S,6S,7R)-2',7'-dibromospiro[1-aza-7-ethoxycarbonyl-3-oxa-8-oxo-2-phenyltricyclo[4.3.0^1,5.0^6,7]nonane-9,9′-fluorene](1169969-36-1)

Safety Data

• Hazardous Substances Data: 1169969-36-1(Hazardous Substances Data)

Upstream product

• 18833-08-4 2,7-dibromo-9-diazo-9H-fluorene 
• 166765-36-2 (2R,5S)-7-ethoxycarbonyl-8-oxo-2-phenyl-1-aza-3-oxa-bicyclo[3.3.0]oct-6-ene 

Relevant articles and documents

Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: Access to annulated prolines

The uncatalysed cycloaddition of substituted diaryldiazo compounds onto bicyclic unsaturated lactams derived from pyroglutamic acid efficiently leads to highly functionalised azatricyclononanes. The products are readily elaborated to deprotected pyroglutamate derivatives, providing rapid access to conformationally constrained amino acids and their analogues. Preliminary assessment of antibacterial activity against one Gram positive and one Gram negative organism indicated high levels of efficacy in some cases.