1169969-38-3Relevant articles and documents
Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: Access to annulated prolines
Harris, Lawrence,Gilpin, Martin,Thompson, Amber L.,Cowley, Andrew R.,Moloney, Mark G.
, p. 6522 - 6550 (2015/06/16)
The uncatalysed cycloaddition of substituted diaryldiazo compounds onto bicyclic unsaturated lactams derived from pyroglutamic acid efficiently leads to highly functionalised azatricyclononanes. The products are readily elaborated to deprotected pyroglutamate derivatives, providing rapid access to conformationally constrained amino acids and their analogues. Preliminary assessment of antibacterial activity against one Gram positive and one Gram negative organism indicated high levels of efficacy in some cases.
A novel class of azatricyclononanes: pentasubstituted cyclopropanes from an uncatalysed reaction
Harris, Lawrence,Gilpin, Martin,Thompson, Amber L.,Cowley, Andrew R.,Moloney, Mark G.
body text, p. 726 - 729 (2009/10/10)
The direct and versatile stereoselective synthesis of a novel class of cyclopropyl derivatives of pyroglutamic acid is reported, using substituted diaryldiazo compounds. The course of the reaction has been investigated, and yields of substituted fluorenyl
