1169983-13-4Relevant academic research and scientific papers
Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions
Yamashita, Yasuhiro,Yoshimoto, Susumu,Dutton, Mark J.,Kobayashi, Sh?
, p. 1447 - 1452 (2016/08/02)
Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3 N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields a
Metal-free asymmetric 1,3-dipolar cycloaddition of N-arylmaleimides to azomethine ylides catalyzed by chiral tertiary amine thiourea
Bai, Jian-Fei,Wang, Liang-Liang,Peng, Lin,Guo, Yun-Long,Ming, Jun-Nan,Wang, Fei-Ying,Xu, Xiao-Ying,Wang, Li-Xin
, p. 4472 - 4478 (2011/10/01)
The first metal-free asymmetric 1,3-dipolar cycloaddition of N-arylmaleimides to azomethine ylides catalyzed by chiral tertiary amine thiourea to form multiply substituted pyrrolidines in excellent yields (up to 89%) and enantioselectivities (up to 96% ee) is presented. This procedure allows a rapid diversity-oriented synthesis of chiral pyrrolidine derivatives with high optical purity. A series of bifunctional thiourea catalysts were applied for the first time to the highly asymmetric 1,3-dipolar cycloaddition of N-arylmaleimides to azomethine ylides togive the products in excellent yields (up to 89%) and enantioselectivities (up to 96% ee).
Highly enantioselective 1,3-dipolar cycloaddition of azomethine ylides catalyzed by AgOAc/TF-BiphamPhos
Wang, Chun-Jiang,Xue, Zhi-Yong,Liang, Gang,Lu, Zhou
supporting information; experimental part, p. 2905 - 2907 (2009/12/01)
A novel and highly efficient AgOAc/TF-BiphamPhos catalytic system shows excellent reactivity, diastereo-/enantioselectivity and structural scope in asymmetric 1,3-dipolar cycloaddition of azomethine ylides, especially derived from various α-substituted α-amino acids, with N-substituted maleimides and other electron-deficient alkenes.
Axially chiral BINIM and Ni(II)-catalyzed highly enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides and N-arylmaleimides
Shi, Jing-Wen,Zhao, Mei-Xin,Lei, Zhi-Yu,Shi, Min
, p. 305 - 308 (2008/09/17)
(Chemical Equation Presented) Axially chiral BINIM-Ni(II) complexes are effective catalysts in the asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides and N-arylmaleimides to give the corresponding adducts in good yields and up to 95% enan
