1170086-89-1

Basic information

• Product Name: 4-oxo-4H-chromene-3-carbothioic acid N-phenylamide
• Synonyms: 4-oxo-4H-chromene-3-carbothioic acid N-phenylamide
• CAS NO: 1170086-89-1
• Molecular Weight: 281.335
• Mol File: 1170086-89-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(1170086-89-1)
• EPA Substance Registry System: 4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(1170086-89-1)

Safety Data

• Hazardous Substances Data: 1170086-89-1(Hazardous Substances Data)

Upstream product

• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 103-72-0 phenyl isothiocyanate 
• 213273-03-1 4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde 

Downstream Products

• 1246216-79-4 2-imino-5-oxo-1-phenyl-1,5-dihydro-2H-chromeno[2,3-b]pyridine-3-carbonitrile 

Relevant articles and documents

Synthesis of 2-aminochromone-3-carbaldehyde hydrazones from 3-thiocarbamoylchromones and hydrazines

Reaction of 3-thiocarbamoylchromones with hydrazines is accompanied by recyclization affording 2-aminochromone-3-carbaldehyde hydrazones.

Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides

6/6,7-Substituted-3-formylchromones (8a-g) were reacted with 2 equivalents thiobenzamide (9) in refluxing toluene to furnish substituted-3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones (10a-g) in high yields. Similarly, when substituted-2-anilino-3-formylchromones (8a-d) were reacted with thiobenzamide (9, 2 equivalents) in refluxing xylene, 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides (11a-d) were obtained in high yields. All the compounds (10a-g) and (11a-d) display significant cytotoxic activity against a number of human cancer cell lines. Among these compounds 10e (IC50?=?10?μM), 10b (IC50?=?14.6?μM) and 10a (IC50?=?10.5?μM) showed maximum cytotoxic activity on neuroblastoma. Also, the compound 10c (IC50?=?10.5?μM) showed maximum cytotoxic activity on ovarian cancer cell line.