106129-86-6

Upstream product

• 1776-09-6 3-bromochroman-4-one 
• 124-40-3 dimethyl amine 
• 118-93-4 o-hydroxyacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 68-12-2 N,N-dimethyl-formamide 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 39079-62-4 chromone-3-carboxylic acid 

Downstream Products

• 61348-47-8 5-(2-hydroxyphenyl)isoxazole 
• 1166821-76-6 N-((4-fluorophenyl)(4-oxo-4H-chromen-3-yl)methyl)acetamide 
• 1166821-69-7 1-((4-Oxo-4H-chromen-3-yl)(p-tolyl)methyl)thiourea 
• 1166821-78-8 1,3-Bis((4-oxo-4H-chromen-3-yl)(p-tolyl)methyl)thiourea 
• 1166821-70-0 1-((4-chlorophenyl)(4-oxo-4H-chromen-3-yl)methyl)thiourea 
• 1166821-79-9 1,3-bis((4-chlorophenyl)(4-oxo-4H-chromen-3-yl)methyl)thiourea 
• 1166821-74-4 1-((4-nitrophenyl)(4-oxo-4H-chromen-3-yl)methyl)urea 
• 1166821-75-5 1-((4-methoxyphenyl)(4-oxo-4H-chromen-3-yl)methyl)urea 
• 1166821-71-1 1-((3-methoxyphenyl)(4-oxo-4H-chromen-3-yl)methyl)thiourea 
• 49619-82-1 3-bromo-4H-chromen-4-one 
• 491-38-3 1-benzopyran-4(4H)-one 

Relevant academic research and scientific papers

A new family of 1D exchange biased heterometal single-molecule magnets: Observation of pronounced quantum tunneling steps in the hysteresis loops of quasi-linear {Mn2Ni3} clusters

First members of a new family of heterometallic Mn/Ni complexes [Mn 2Ni3X2L4(LH)2(H 2O)2] (X = Cl: 1; X = Br: 2) with the new ligand 2-{3-(2-hydroxyphenyl)-1H-pyrazol-1-yl}ethanol (H2L) have been synthesized, and single crystals obtained from CH2Cl2 solutions have been characterized crystallographically. The molecular structures feature a quasi-linear MnIII-NiII-NiII-Ni II-MnIII core with six-coordinate metal ions, where elongated axes of all the distorted octahedral coordination polyhedra are aligned parallel and are fixed with respect to each other by intramolecular hydrogen bonds. 1 and 2 exhibit quite strong ferromagnetic exchange interactions throughout (JMn-Ni ≈ 40 K (1) or 42 K (2); JNi-Ni ≈ 22 K (1) or 18 K (2)) that lead to an Stot = 7 ground state, and a sizable uniaxial magnetoanisotropy with Dmol values -0.55 K (1) and -0.45 K (2). These values are directly derived also from frequency- and temperature-dependent high-field EPR spectra. Slow relaxation of the magnetization at low temperatures and single-molecule magnet (SMM) behavior are evident from frequency-dependent peaks in the out-of-phase ac susceptibilities and magnetization versus dc field measurements, with significant energy barriers to spin reversal Ueff = 27 K (1) and 22 K (2). Pronounced quantum tunnelling steps are observed in the hysteresis loops of the temperature- and scan rate-dependent magnetization data, but with the first relaxation step shifted above (1) or below (2) the zero crossing of the magnetic field, despite the very similar molecular structures. The different behavior of 1 and 2 is interpreted in terms of antiferromagnetic (1) or ferromagnetic (2) intermolecular interactions, which are discussed in view of the subtle differences of intermolecular contacts within the crystal lattice.

Analogues of Dehydroacetic Acid as Selective and Potent Agonists of an Ectopic Odorant Receptor through a Combination of Hydrophilic and Hydrophobic Interactions

Identification of potent agonists of odorant receptors (ORs), a major class of G protein-coupled receptors, remains challenging due to complex receptor–ligand interactions. ORs are present in both olfactory and non-chemosensory tissues, indicating roles beyond odor detection that may include modulating physiological functions in non-olfactory tissues. Selective and potent agonists specific for particular ORs can be used to investigate physiological functions of ORs in non-chemosensory tissues. In this study, we designed and synthesized novel synthetic dehydroacetic acid analogues as agonists of odorant receptor 895 (Olfr895) expressed in bladder. Among the synthesized analogues, (E)-3-((E)-1-hydroxy-3-(piperidin-1-yl)allylidene)-6-methyl-2H-pyran-2,4(3H)-dione (10) exhibited extremely high agonistic activity for Olfr895 in Dual-Glo luciferase reporter (EC50=9 nm), Ca2+ imaging, and chemotactic migration assays. Molecular docking and site-directed mutagenesis studies suggested that a combination of hydrophilic and hydrophobic interactions is central to the selective and specific binding of 10 to Olfr895. The design of agonists armed with both hydrophilic and hydrophobic portions could therefore lead to highly potent and selective ligands for ectopic ORs.

Chromenone-rhodamine conjugate for naked eye detection of Al3+ and Hg2+ ions in semi aqueous medium

Chromenone-rhodamine conjugate 1 has been synthesized and its metal ion binding properties have been studied in CH3CN/water (3:1, v/v; 10?mM HEPES buffer; pH?=?6.85). Compound 1 senses multiple metal ions such as Al3+ and Hg2+/

Reusable manganese compounds containing pyrazole-based ligands for olefin epoxidation reactions

We describe the synthesis of new manganese(ii) and manganese(iii) complexes containing the bidentate ligands 2-(3-pyrazolyl)pyridine, pypz-H, and 3(5)-(2-hydroxyphenyl)pyrazole, HOphpz-H, with formula [MnX2(pypz-H)2] (X = Cl-, 1, CF3SO3-, 2, OAc-, 3 or NO3- (4)), [MnCl2(pypz-H)(H2O)2], 5, or [MnCl(Ophpz-H)2], 6. All the complexes have been characterized through analytical, spectroscopic and electrochemical techniques. Single X-ray structure analysis revealed a six-coordinated Mn(ii) ion in complexes 1-5, and a five-coordinated Mn(iii) ion in complex 6. Compound 5 is the first co-crystal of Mn(ii) containing Cl and H2O ligands together with bidentate nitrogen ligands. The catalytic activity of complexes 1-6 has been tested with regard to the epoxidation of styrene and, in the case of 1, 5 and 6, other alkenes have been epoxidized using peracetic acid as oxidant in different media, among which glycerol, a green solvent never used in epoxidation reactions using peracetic acid as oxidant. The catalysts show moderate to high conversions and selectivities towards the corresponding epoxides. For complexes 1, 5 and 6, a certain degree of cis → trans isomerization is observed in the case of cis-β-methylstyrene. These observations have been explained through computational calculations. The reutilization of catalysts 1 and 6 for the epoxidation of alkenes has been evaluated in [bmim]:acetonitrile mixture (bmim = 1-butyl-3-methylimidazolium), allowing the effective recyclability of the catalytic system and keeping high conversion and selectivity values up to 12 successive runs, in all cases.

A Convenient and Practical Synthesis of Aminopyrazoles

A selective methodology for preparing highly substituted aminopyrazoles has been demonstrated. Starting with an acetophenol core, the corresponding substituted isoxazole is prepared in two steps. The isoxazole is transformed into a benzopyran. Alkylation

Selectfluor-Mediated Tandem Cyclization of Enaminones for the Synthesis of 3-Fluorochromones

An efficient synthesis of various 3-fluorochromones (3-fluoro-4 H -chromene-4-ones) from enamino ketones by using Selectfluor is described. The key step in the synthesis involves tandem fluorination and cyclization to form 3-fluorochromones in good yields. The significant features of this method include simple operational procedures, a high purity of the product, and excellent regioselectivity.

2-Azolylchromone derivatives as potent and selective inhibitors of monoamine oxidases A and B

A series of 2-azolylchromone derivatives were synthesized and their monoamine oxidase (MAO) A and B inhibitory activities were evaluated. Of the synthesized compounds, compounds 1b, 2b, 4a-c, 5b and 7b showed potent inhibitory activities against MAO-A (IC50 values, 1b: 0.32 μM; 2b: 0.14 μM; 4a: 0.11 μM; 4b: 0.023 μM; 4c: 0.15 μM; 5b: 0.59 μM; 7b: 0.19 μM) and 4a, c, 5a, c, 6c and 8c for MAO-B (IC50 values, 4a: 0.028 μM; 4c: 0.019 μM; 5a: 0.73 μM; 5c: 0.28 μM; 6c: 0.28 μM; 8c: 0.27 μM). These data suggest that 6-methoxy substitution favors MAO-A inhibition and 7-methoxy substitution favors MAO-B inhibition. In addition, compound 4b was the most potent inhibitor for MAO-A, and compound 4c for MAO-B. This is the first report identifying 2-azolylchromone derivatives as potent monoamine oxidase inhibitors. These results suggest that the 2-triazolylchromone structure may be a useful scaffold for the design and development of novel monoamine oxidase inhibitors, as evidenced by the activities of 4a-c and 5a-c.

Synthesis and antitubercular activity evaluation of 4-furano-coumarins and 3-furano-chromones

The synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C–H/C–H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%–90% and 82%–90% yields, respectively. The st

Visible Light-Promoted Selenylation/Cyclization of Enaminones toward the Formation of 3-Selanyl-4H-Chromen-4-Ones

A simple and efficient visible-light-promoted selenylation/cyclization of enaminones have been realized for the practical synthesis of 3-selanyl-4H-chromen-4-ones. This reaction is performed in the mild conditions, no transition metal catalyst or photocatalysts and no additional oxidants are required. In addition, the 3-selanyl-4H-chromen-4-ones could be easily converted to selanyl-functionalized pyrimidines by reacting with benzamidine substrates. (Figure presented.).

Synthesis of new hybrid heterocyclic compounds having 1,2,3-triazole and isoxazole via click chemistry

A simple and highly efficient method for the regioselective synthesis of isoxazolyl-1,4-disubstituted-1,2,3-triazoles 6a-l in good to excellent yields from terminal alkynes having isoxazole scaffold 4a-c and various azides through Cu(I)-catalyzed 1,3-dipolar cycloaddition is described. The reaction proceeds smoothly in 1:1 mixture of t-BuOH and water at RT. The structures of all newly synthesized hybrid heterocycles are established on the basis of spectral data ir, 1H nmr, mass, and elemental analysis.