1170193-30-2

Upstream product

• 1170193-39-1 5-bromo-2,3-dihydro-1,1-dioxothieno[2,3-d]isothiazole 
• 1170193-38-0 5-bromo-2-(bromomethyl)thiophen-3-sulfonamide 
• 1170193-35-7 5-bromo-2-(hydroxymethyl)thiophen-3-sulfonamide 
• 59337-93-8 Methyl 3-sulfamoylthiophene-2-carboxylate 
• 1170193-41-5 methyl 2-{5-bromo-1,1-dioxothieno[2,3-d]isothiazole-2(3H)-yl}butyrate 
• 536-74-3 phenylacetylene 

Downstream Products

• 1170194-08-7 C₁₇H₁₅NO₄S₂ 

Relevant academic research and scientific papers

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors

A series of 1,1-dioxothieno[2,3-d]isothiazole (thienosultam) derivatives were designed and synthesized as novel ADAMTS-5 inhibitors for an investigation into a side chain of thienosultam for the S1′ pocket. The resulting compounds (19 and 24) show high AD

SULTAM DERIVATIVES

A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mamma