59337-93-8

Basic information

• Product Name: Methyl 3-aminosulfonylthiophene-2-carboxylate
• Synonyms: 3-(aminosulfonyl)-2-thiophenecarboxylicacimethylester;methyl3-(aminosulfonyl)-2-thiophenecarboxylate;METHYL 3-SULFAMOYLTHIOPHENE-2-CARBOXYLA&;methyl 3-Sulfonyl amino-2-thiophenecarboxylate;Methyl 3-aminosulfonylthiophene-2-carboxylate;2-(METHOXYCARBONYL)-THIOPHENE-3-SULFON-AMID;methyl-(3-aminosulfonylthiophen-2-carboxylate);2-Thiophenecarboxylic acid, 3-(aminosulfonyl)-, methyl ester
• CAS NO: 59337-93-8
• Molecular Formula: C₆H₇NO₄S₂
• Molecular Weight: 221.25
• Mol File: 59337-93-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 123-124 °C(Solv: water (7732-18-5))
• Boiling Point: 428.3 °C at 760 mmHg
• Flash Point: 212.8 °C
• Appearance: /
• Density: 1.517 g/cm³
• Vapor Pressure: 1.53E-07mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.55±0.60(Predicted)
• CAS DataBase Reference: Methyl 3-aminosulfonylthiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-aminosulfonylthiophene-2-carboxylate(59337-93-8)
• EPA Substance Registry System: Methyl 3-aminosulfonylthiophene-2-carboxylate(59337-93-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 59337-93-8(Hazardous Substances Data)

Usage

Uses

Methyl 3-Aminosulfonyl-2-thiopene Carboxylate is an intermediate in the synthesis of Thifensulfuron-methyl (T344700), a sulfonylurea herbicide.

InChI:InChI=1/C6H7NO4S2/c1-11-6(8)5-4(2-3-12-5)13(7,9)10/h2-3H,1H3,(H2,7,9,10)

Upstream product

• 79277-27-3 thifensulfuron methyl 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 150258-68-7 methyl 3-[({[(4-hydroxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]-2-thiophene methyl carboxylate 
• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 

Downstream Products

• 1170193-30-2 Methyl 2-(5-(phenylethynyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate 
• 1170194-08-7 C₁₇H₁₅NO₄S₂ 
• 1428510-69-3 C₁₉H₂₃N₃O₄S₂ 
• 1170193-33-5 5-bromo-2-((tert-butyldiphenylsiloxy)methyl)thiophen-3-sulfonamide 
• 1170193-31-3 2-((tert-butyldiphenylsiloxy)methyl)thiophen-3-sulfonamide 
• 1170195-30-8 C₁₉H₁₉N₃O₄S₂ 
• 1170194-94-1 C₁₉H₂₀N₂O₄S₂ 
• 1170195-07-9 C₁₈H₁₆F₃NO₄S₂ 
• 1170195-00-2 C₂₃H₁₉NO₄S₂ 
• 1170194-91-8 C₁₉H₁₃F₆NO₄S₂ 
• 1170194-86-1 C₁₈H₂₃NO₄S₂ 
• 119120-83-1 1-(1,1-Dioxo-1H-1λ⁶-thieno[2,3-d]isothiazol-3-yl)-1H-benzotriazole 
• 113387-69-2 3-(4-Chloro-3,5-dimethyl-pyrazol-1-yl)-thieno[2,3-d]isothiazole 1,1-dioxide 
• 113387-70-5 1-(1,1-Dioxo-1H-1λ⁶-thieno[2,3-d]isothiazol-3-yl)-1H-indazole 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Rearrangement products in aqueous photolysis of thifensulfuron methyl

Photo-degradation of [14C]-thifensulfuron methyl has been investigated in aqueous media using a light source which simulates sunlight. Degradation of thifensulfuron methyl proceeds predominantly via sulfonylurea bridge ipso-contraction, and via cleavage of the bridge structure, to yield products in which the thiophene and the triazine rings have disconnected. One significant degradation product, which accounts for nearly 10%, retained both rings with truncated bridge moiety. Surprisingly, this product had thiophene ring substituents rearranged from their original locations. Other laboratories have reported photodegradation of thifensulfuron-methyl, and identified similar degradation products as well. The structure of the rearrangement product has been misidentified in previous reports because the rearrangement of the thiophene ring is not widely recognized. An unambiguous identification of this product and potential rearrangement mechanisms are presented in this report.

SULTAM DERIVATIVES

A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mamma