1170613-83-8

Basic information

• Product Name: (E)-ethyl 3-(2-fluorophenyl)-2-methylacrylate
• Synonyms: (E)-ethyl 3-(2-fluorophenyl)-2-methylacrylate
• CAS NO: 1170613-83-8
• Molecular Weight: 208.232
• Mol File: 1170613-83-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 3-(2-fluorophenyl)-2-methylacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(2-fluorophenyl)-2-methylacrylate(1170613-83-8)
• EPA Substance Registry System: (E)-ethyl 3-(2-fluorophenyl)-2-methylacrylate(1170613-83-8)

Safety Data

• Hazardous Substances Data: 1170613-83-8(Hazardous Substances Data)

Upstream product

• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 446-52-6 2-Fluorobenzaldehyde 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 

Downstream Products

• 1170613-86-1 (E)-3-(2-fluorophenyl)-N-methoxy-N,2-dimethylacrylamide 
• 1170613-58-7 (1E,3E)-1-(2-fluorophenyl)-2-methylpent-1-en-3-one oxime 
• 1170613-88-3 (E)-1-(2-fluorophenyl)-2-methylpent-1-en-3-one 

Relevant articles and documents

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

TRPA1 antagonists

Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds