117067-06-8

Basic information

• Product Name: 3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol
• Synonyms: 3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol
• CAS NO: 117067-06-8
• Molecular Weight: 266.34
• Mol File: 117067-06-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol(117067-06-8)
• EPA Substance Registry System: 3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol(117067-06-8)

Safety Data

• Hazardous Substances Data: 117067-06-8(Hazardous Substances Data)

Upstream product

• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 96-24-2 3-monochloro-1,2-propanediol 
• 556-52-5 oxiranyl-methanol 
• 57149-07-2 naftopidil 

Relevant articles and documents

Microwave-assisted ring opening of epoxides: A general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities

A series of 1-aminopropan-2-ols were synthesized and evaluated against two strains of malaria, Plasmodium falciparum FCR3 (chloroquine-resistant) and 3D7 (chloroquine-sensitive). Microwave-assisted ring opening of epoxides (aryl and alkyl glycidyl ethers,

Metabolic fate of the novel antihypertensive drug naftopidil

The metabolism of 14C-naftopidil ((R,S)-1-(2-methoxyphenyl)-1-piperazinyl-3-(1-naphthyl-oxy)-2-propanol , CAS 57149-07-2) and the pharmacodynamic action of the metabolites was investigated. The metabolic pathway in rat, dog, mouse and man was qualitatively similar, with preference for the hydroxylation of the phenyl or naphthyl moiety of naftopidil ((phenyl)hydroxy-metabolite, (naphthyl)hydroxy-metabolite). Cleavage of the parent compound and production of the propylene glycol metabolite was a further important reaction especially for rat and man. In all species investigated, demethylation of naftopidil occurs to a minor extent. O-desmethyl-naftopidil, (phenyl)hydroxy-naftopidil and (naphthyl)hydroxy-naftopidil were found to have similar affinities for the α1-adrenoceptors as the parent compound (IC50(nmol/l): 433.0; 585.0; 52.7; respectively; naftopidil: 235.0). The naftopidil metabolites, like the parent compound showed no α2- or β-adrenoceptor affinity.