117106-15-7Relevant articles and documents
Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)?H Carbamoylation
Dailler, David,Rocaboy, Ronan,Baudoin, Olivier
, p. 7218 - 7222 (2017/06/13)
A general and user-friendly synthesis of β-lactams is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)?H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C?H bonds, in contrast to previous methods based on C(sp3)?H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.
(Chloromethylene)dimethylammonium chloride: A highly efficient reagent for the synthesis of β-lactams from β-amino acids
Kanwar, Seema,Sharma, Sain D.
, p. 705 - 707 (2007/10/03)
(Chloromethylene)dimethylammonium chloride 1, is a unique reagent that conveniently and efficiently mediates the amide bond formation in β-lactams via cyclodehydration of β-amino acids leading to β-lactam formation. The process involves the formation of a highly reactive activated ester of a β-amino acid which gets cyclised to the corresponding β-lactam in excellent yield. The reaction proceeds smoothly and cleanly as the by-products formed are the water soluble-dimethyl formamide and triethylamine hydrochloride.
ARYL BIS (2-OXO-3-BENZOXAZOLINYL)PHOSPHINATE AND TRIS(2-OXO-3-BENZOXAZOLINYL)PHOSPHINE OXIDE: NEW CONDENSING REAGENTS FOR BETA-LACTAM FORMATION FROM BETA-AMINO ACIDS
Nagamatsu, Tomohisa,Kunieda, Takehisa
, p. 1249 - 1251 (2007/10/02)
Beta-lactam compounds including the penam, a basic skeleton of penicillins, are conveniently prepared by the dehydration of β-amino acids using new condensing reagents which are titled.Keywords - β-lactam; β-amino acid; penam; condensing reagent; 2-benzox
