117106-22-6

Usage

Uses

Used in Pharmaceutical Industry:
(S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid is used as a potential pharmaceutical compound for its unique structure and properties, which may contribute to the development of new drugs or therapies.
Used in Materials Science:
(S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid is used as a potential material in materials science due to its complex structure, which may offer novel properties for the development of advanced materials.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 1482-98-0 (S)-2,4-diaminobutyric acid dihydrochloride 
• 117106-21-5 N^α-t-Boc-N^γ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid 

Downstream Products

• 1072896-05-9 N^γ-Fmoc-N^α-[N⁶-(benzhydryloxycarbonyl)-(adenin-9-yl)acetyl]-2,4-diaminobutyric acid 
• 117106-21-5 N^α-t-Boc-N^γ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid 

Relevant academic research and scientific papers

dabPNA: Design, synthesis, and DNA binding studies

In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs. Copyright Taylor & Francis Group, LLC.

Evidences for complex formation between l-dabPNA and aegPNA

Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.