117111-06-5Relevant academic research and scientific papers
Catalytic synthesis method of 1,3-dicarbonyl compounds
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Paragraph 0025; 0026; 0028; 0029; 0030; 0031; 0032, (2019/01/07)
The invention discloses a catalytic synthesis method of 1,3-dicarbonyl compounds. According to the catalytic synthesis method, with the participation of sodium carbonate, aniline compounds and ethyl bromide difluoroacetate are subjected to defluorination
Synthesis of β-Aminoenones via Cross-Coupling of In-Situ-Generated Isocyanides with 1,3-Dicarbonyl Compounds
Ma, Xingxing,Zhou, Yao,Song, Qiuling
supporting information, p. 4777 - 4781 (2018/08/24)
An efficient and practical strategy for the synthesis of β-aminoenones from a three-component reaction was developed. Ethyl bromodifluoroacetate serves as a C1 source in this strategy, forming isocyanides in situ with primary amines. This reaction represents the first example of utilization of readily available starting materials to generate isocyanides in situ and sequentially fully converted to β-aminoenones, avoiding the generation of byproduct imines and overinsertion products. The mechanism study suggested that this method involves activation of two C(sp3)-F bonds and the formation of isocyanides, which might nourish both isocyanide chemistry and fluorine chemistry.
Intermolecular Thermal Reaction of Arylnitrenes with Furans
Benati, Luisa,Montevecchi, Pier Carlo,Toselli, Maurizio,Spagnolo, Piero
, p. 1859 - 1864 (2007/10/02)
4-Methoxy-, 4-chloro-, and 4-nitro-phenylnitrenes have been thermally generated by decomposition of the corresponding aryl azides in the presence of furan and a series of 2-substituted and 2,5-disubstituted furans. 4-Nitrophenylnitrene has been shown to be capable of undergoing electrophilic addition to the furan ring both at the α- and β-position, whereas only evidence of α-attack has been provided by 4-chlorophenylnitrene.On the other hand, no evidence of electrophilic attack has been obtained with 4-methoxyphenylnitrene, which affords only products ascribable to the triplet nitrene.The formation of a number of products ultimately resulting from nitrene attack at the α-position of the furan ring followed by a ring-opening process and the general occurrence of 1-(4-nitrophenyl)- and 1-(4-chlorophenyl)-1,2,3-triazole from thermolysis of 4-nitro- or 4-chloro-phenyl azide in the presence of the furans examined is discussed.
