1171331-39-7

Basic information

• Product Name: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride
• Synonyms: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride
• CAS NO: 1171331-39-7
• Molecular Formula: C₄H₇F₃N₂O*ClH
• Molecular Weight: 192.5673296
• Product Categories: Intermediates
• Mol File: 1171331-39-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride(1171331-39-7)
• EPA Substance Registry System: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride(1171331-39-7)

Safety Data

• Hazardous Substances Data: 1171331-39-7(Hazardous Substances Data)

Usage

Uses

Reactant in the synthesis of isoxazoline indolizine amides.

Upstream product

• 1231755-15-9 2-N-(tert-butoxycarbonyl)-1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane 
• 1371632-80-2 2-[bis(phenylmethyl)amino]-N-(2,2,2-trifluoroethyl)acetamide 
• 1371632-79-9 phenylmethyl N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate 
• 359821-38-8 2-ammonia-N-(2,2,2-trifluoroethyl)acetamide 

Downstream Products

• 864731-61-3 A₁₄₄₃ 
• 1369852-71-0 (S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide 
• 1093861-60-9 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 
• 1122022-02-9 A664 
• 1312697-19-0 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)indolizine-8-carboxamide 
• 1444176-77-5 4-[5-(3,5-dichlorophenyl)-4-fluoro-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide 
• 1427273-67-3 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide 
• 1416977-61-1 (Z)-2-Bromo-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 2-AMINO-N-(2,2,2-TRIFLUOROETHYL)-ACETAMIDE AND SALTS THEREOF

The present invention relates to an improved process for the preparation of 2-amino-N-(2,2,2-trifluoroethyl) acetamide of formula (I) and salts (IA) thereof, in an environment friendly and commercially viable manner in high yield and greater chemical purity.

2-amino-N-(2, 2, 2-trifluoroethyl) or its salt aminoacetamide compd.

PROBLEM TO BE SOLVED: To provide a method for producing a substituted 2-amino-N-(2,2,2-trifluoroethyl)acetamide or a salt thereof. SOLUTION: The method for producing 2-amino-N-(2,2,2-trifluoroethyl)acetamide or a salt thereof comprises, as shown in chemical reaction formula (A), reaction of 2,2,2-trifluoroethylamine or a salt thereof with an acyl compound preferably in the presence of water and an inorganic base, and through this compound, the objective 2-amino-N-(2,2,2-trifluoroethyl)acetamide or a salt thereof is obtained. COPYRIGHT: (C)2009,JPO&INPIT

METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE

Disclosed are methods for preparing compounds of Formula 1 and 1A. The first method utilizes a benzyl carbamate amine protecting group and an intermediate of Formula 4. The second method utilizes a tert-butyl carbamate amine protecting group and an interm