117145-60-5

Basic information

• Product Name: 6-nitro-2-(4-t-butylphenyl)-4H-3,1-benzoxazin-4-one
• Synonyms: 6-nitro-2-(4-t-butylphenyl)-4H-3,1-benzoxazin-4-one
• CAS NO: 117145-60-5
• Molecular Weight: 324.336
• Mol File: 117145-60-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-nitro-2-(4-t-butylphenyl)-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-2-(4-t-butylphenyl)-4H-3,1-benzoxazin-4-one(117145-60-5)
• EPA Substance Registry System: 6-nitro-2-(4-t-butylphenyl)-4H-3,1-benzoxazin-4-one(117145-60-5)

Safety Data

• Hazardous Substances Data: 117145-60-5(Hazardous Substances Data)

Upstream product

• 616-79-5 2-amino-5-nitro-benzoic acid 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 79-37-8 oxalyl dichloride 
• 219491-90-4 2-[(4-tert-butylbenzoyl)amino]-5-nitrobenzoic acid 

Downstream Products

• 219508-05-1 2-[(4-t-butylbenzoyl)amino]-N-(6-indolyl)-5-nitrobenzamide 
• 219507-97-8 2-[(4-t-butylbenzoyl)amino]-N-(6-indazolyl)-5-nitrobenzamide 
• 117145-62-7 2-[4-(1,1-dimethylethyl)phenyl]-6-phenylsulfamoyl-4H-3,1-benzoxazin-4-one 
• 117145-63-8 2-[4-(1,1-dimethylethyl)phenyl]-6-methylsulfamoyl-4H-3,1-benzoxazin-4-one 
• 219491-73-3 2-(4-tert-butylbenzoylamino)-5-amino-N-(4-methoxyphenyl)benzamide 
• 219491-91-5 2-(4-tert-butylbenzoylamino)-5-nitro-N-(4-methoxyphenyl)benzamide 
• 117145-61-6 6-amino-2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

Antithrombotic agents

This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

N2-aroylanthranilamide inhibitors of human factor Xa

Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K(ass) = 0.81 x 106 L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N2-aroylanthranilamide 4. Expansion of the SAR around 4 showed that only smal