117153-32-9

Upstream product

• 17460-45-6 tetra-acetyl glucosamine 
• 99-33-2 3,5-dinitrobenoyl chloride 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 17460-45-6 1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-alpha-D-glucopyranose 
• 51471-40-0 6-(hydroxymethyl)-3-[4-methoxybenzylideneamino]tetrahydropyran-2,4,5-triol 
• 5432-46-2 1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride 
• 7597-81-1 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(4-methoxybenzylidene)amino-β-D-glucopyranose 

Downstream Products

• 59676-32-3 2-(3,5-dinitro-benzoylamino)-2-deoxy-D-glucose 

Relevant academic research and scientific papers

Synthesis of NAG-thiazoline-derived inhibitors for β-N-acetyl-d-hexosaminidases

Abstract β-N-Acetyl-d-hexosaminidases are responsible for the metabolism of glycoconjugates in diverse physiological processes that are important targets for medicine and pesticide development. Fourteen new NAG-thiazoline derivatives were synthesized by cyclization and click reaction using d-glucosamine hydrochloride as the starting material. All the compounds created were characterized by NMR and HRMS spectra. A preliminary bioassay, using four enzymes from two β-N-acetyl-d-hexosaminidase families, showed that most of the compounds synthesized exhibit selective inhibition of GH84 β-N-acetyl-d-hexosaminidase. Among the compounds tested, compounds 5a (IC50=12.6 μM, hOGA) and 5e (IC50=12.5 μM, OfOGA) proved to be a highly selective and potent inhibitor.