117155-90-5

Upstream product

• 463-71-8 thiophosgene 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 75-15-0 carbon disulfide 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 

Downstream Products

• 1000991-95-6 C₄₈H₇₄N₄O₁₂S 
• 1198297-74-3 (S)-tert-butyl 2-{3-[(1S,2S)-2-amino-1,2-diphenylethyl]thioureido}-3-phenylpropanoate 
• 1431526-48-5 tert-butyl N-(1-methyl-1H-benzimidazol-2-yl)L-phenylalaninate 
• 1447570-55-9 tert-butyl N-(1H-benzimidazol-2-yl)L-phenylalaninate 

Relevant academic research and scientific papers

Synthesis, biological activity and in silico pharmacokinetic prediction of a new 2-thioxo-imidazoldidin-4-one of primaquine

The discovery of novel antiparasitic drugs for neglected tropical diseases (NTDs) constitutes a global urgency and requires a range of innovative strategies to ensure a sustainable pipeline of lead compounds. Thus far, primaquine (PQ) is the only transmis

Iodoacetic acid is an efficient reagent for the synthesis of amino acid derived 2-aminobenzimidazoles

Chiral, nonracemic, N-unprotected amino acids were converted into the corresponding N-benzimidazol-2-yl derivatives by a sequential procedure involving initial formation of isothiocyanates, their reaction with arene-1,2-diamines, and cyclization-desulfurization of the intermediate thioureas with iodoacetic acid. The simplified workup and the lack of volatile or toxic byproducts in the key desulfurization step renders iodoacetic acid a superior reagent to the usual reagent, iodomethane. Georg Thieme Verlag Stuttgart · New York.

Enantioselective aza-Michael addition of imides by using an integrated strategy involving the synthesis of a family of multifunctional catalysts, usage of multiple catalysis, and rational design of experiment

A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational explo

Primary amine-thioureas based on tert-butyl esters of natural amino acids as organocatalysts for the Michael reaction

A new class of primary amine-thioureas based on tert-butyl esters of (S)-α-amino acids and (1S,2S)-diphenylethylenediamine was synthesized and their activity as catalysts in Michael additions was evaluated. Derivatives based on di-tert-butyl aspartate and

A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate

Alkyl and aryl amines are converted smoothly to the corresponding isothiocyanates via the dithiocarbamates in good to excellent yields using di-tert-butyl dicarbonate (Boc2O) and 1-3 mol % of DMAP or DABCO as catalyst. As most of the byproducts are volatile, the work-up involves simple evaporation of the reaction mixture.

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

Two new GdEGTA (EGTA = ethylene glycol-bis(2-aminoethylether)-N,N,N′, N′-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecede