1172-98-1Relevant academic research and scientific papers
Palladium-Catalyzed Direct Decarbonylative Phosphorylation of Benzoic Acids with P(O)–H Compounds
Zhang, Ji-Shu,Chen, Tieqiao,Han, Li-Biao
, p. 1148 - 1153 (2020)
A direct decarbonylative phosphorylation of benzoic acids catalyzed by palladium was disclosed. Under the reaction conditions, a wide range of benzoic acids coupled readily with all the three kinds of P(O)–H compounds, i.e. secondary phosphine oxides, H-phosphinates and H-phosphonates, producing the corresponding organophosphorus compounds in good to high yields. This reaction could be conducted at a gram scale and applied in the late-stage phosphorylative modification of carboxylic acids drug molecules. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis.
Aromatic phosphorus oxide compounds and preparation method for aromatic phosphorus oxide medicines of same
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Paragraph 0041-0042, (2019/12/25)
The invention discloses a plurality of aromatic phosphorus oxide compounds and a preparation method of aromatic phosphorus oxide medicines of the same. The preparation method comprises the following steps: weighing 1.2 times equivalent of aromatic carboxy
Ni-Catalyzed C-P Coupling of Aryl, Benzyl, or Allyl Ammonium Salts with P(O)H Compounds
Yang, Bo,Wang, Zhong-Xia
, p. 1500 - 1509 (2019/02/07)
A methodology that allows for the construction of C-P bonds via the nickel-catalyzed cross-coupling of organoammonium salts with appropriate phosphorus nucleophiles has been developed. Aryl-, pyridyl-, benzyl-, and allyl-ammonium triflates can be employed as the electrophiles. The employed phosphorus-based nucleophiles included diaryl/dibutyl phosphine oxide, dialkyl phosphonates, and ethyl phenylphosphinate. Functional groups OMe, CN, CF3, F, Cl, C(O)NMe2, and C(O)tBu were tolerated.
Synthesis of phosphine oxide-carboxylic acid esters bearing 9,10-dihydro-9,10-ethanoanthracene moiety
Okada, Yoshiharu,Okeya, Kazuhiro,Murata, Yoshiyasu,Aoki, Nakahisa,Aoki, Takahiro,Sugitani, Motoko,Yasui, Satomi,Sawada, Yusuke,Ogura, Fumio
, p. 821 - 829 (2007/10/03)
A bulky type of phosphine oxide-carboxylic acid bearing 9,10-dihydro-9,10-ethanoanthracene moiety was synthesized by the Diels-Alder reaction of 2-anthryldiphenylphosphine oxide and methyl acrylate, for which the structure was confirmed on the basis of s
