117200-36-9Relevant academic research and scientific papers
Identification of an indole series of prostaglandin D2 receptor antagonists
Sturino, Claudio F.,Lachance, Nicolas,Boyd, Michael,Berthelette, Carl,Labelle, Marc,Li, Lianhai,Roy, Bruno,Scheigetz, John,Tsou, Nancy,Brideau, Christine,Cauchon, Elizabeth,Carriere, Marie-Claude,Denis, Danielle,Greig, Gillian,Kargman, Stacia,Lamontagne, Sonia,Mathieu, Marie-Claude,Sawyer, Nicole,Slipetz, Deborah,O'Neill, Gary,Wang, Zhaoyin,Zamboni, Robert,Metters, Kathleen M.,Young, Robert N.
, p. 3043 - 3048 (2008/09/21)
A novel indole series of PGD2 receptor (DP receptor) antagonists is presented. Optimization of this series led to the identification of potent and selective DP receptor antagonists. In particular, antagonists 35 and 36 were identified with Ksu
Tetrahydrocarbazole esters, pharmaceutical compositions and use
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, (2008/06/13)
Tetrahydrocarbazole esters are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
